Sökning: onr:"swepub:oai:lup.lub.lu.se:e8d7ef7a-50b4-48da-b45c-c6cd5783e71f" >
Cause of death base...
-
Romanova, E. S.North-Western State Medical University named after I.I. Mechnikov
(författare)
Cause of death based on systematic post-mortem studies in patients with positive SARS-CoV-2 tissue PCR during the COVID-19 pandemic
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
-
2021-05-20
-
Wiley,2021
-
11 s.
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:e8d7ef7a-50b4-48da-b45c-c6cd5783e71f
-
https://lup.lub.lu.se/record/e8d7ef7a-50b4-48da-b45c-c6cd5783e71fURI
-
https://doi.org/10.1111/joim.13300DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
Importance: Assessment of the causative association between the COVID-19 and cause of death has been hampered by limited availability of systematically performed autopsies. We aimed to present autopsy-confirmed causes of death in patients who died with COVID-19 and to assess the association between thrombosis and diffuse alveolar damage consistent with COVID-19 (DAD). Methods: Consecutive forensic (n = 60) and clinical (n = 42) autopsies with positive post-mortem SARS-CoV-2 PCR in lungs (age 73 ± 14 years, 50% men) were included. The cause of death analysis was based on a review of medical records and histological reports. Thrombotic phenomena in lungs were defined as pulmonary thromboembolism (PE), thrombosis in pulmonary artery branches or microangiopathy in capillary vessels. Results: COVID-19 caused or contributed to death in 71% of clinical and 83% of forensic autopsies, in whom significant DAD was observed. Of the patients with COVID-19 as the primary cause of death, only 19% had no thrombotic phenomena in the lungs, as opposed to 38% amongst those with COVID-19 as a contributing cause of death and 54% amongst patients whose death was not related to COVID-19 (p = 0.002). PE was observed in 5 patients. Two patients fulfilled the criteria for lymphocyte myocarditis. Conclusions: Vast majority of all PCR-positive fatalities, including out-of-hospital deaths, during the SARS-CoV-2 pandemic were related to DAD caused by COVID-19. Pulmonary artery thrombosis and microangiopathy in pulmonary tissue were common and associated with the presence of DAD, whilst venous PE was rarely observed. Histology-confirmed lymphocyte myocarditis was a rare finding.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Vasilyev, V. V.North-Western State Medical University named after I.I. Mechnikov
(författare)
-
Startseva, G.North-Western State Medical University named after I.I. Mechnikov
(författare)
-
Karev, V.Pediatric Research and Clinical Center for Infectious Diseases, St. Petersburg
(författare)
-
Rybakova, M. G.Pavlov University
(författare)
-
Platonov, P. G.Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)kard-ppl
(författare)
-
North-Western State Medical University named after I.I. MechnikovPediatric Research and Clinical Center for Infectious Diseases, St. Petersburg
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of Internal Medicine: Wiley290:3, s. 655-6650954-68201365-2796
Internetlänk
Hitta via bibliotek
Till lärosätets databas