Sökning: onr:"swepub:oai:lup.lub.lu.se:e9f7b906-4be1-43e9-b21b-aea12b74ef72" >
Level of sedation i...
Level of sedation in critically ill adult patients : a protocol for a systematic review with meta-analysis and trial sequential analysis
-
- Ceric, Ameldina (författare)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Holgersson, Johan (författare)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- May, Teresa (författare)
- Maine Medical Center
-
visa fler...
-
- Skrifvars, Markus B. (författare)
- University of Helsinki
-
- Hästbacka, Johanna (författare)
- Helsinki University Central Hospital
-
- Saxena, Manoj (författare)
- University of New South Wales
-
- Aneman, Anders (författare)
- University of New South Wales
-
- Delaney, Anthony (författare)
- University of New South Wales,Royal North Shore Hospital
-
- Reade, Michael C. (författare)
- University of Southern Denmark
-
- Delcourt, Candice (författare)
- Macquarie University, Sydney
-
- Jakobsen, Janus (författare)
- University of Southern Denmark
-
- Nielsen, Niklas (författare)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Kliniska Vetenskaper, Helsingborg,Institutionen för kliniska vetenskaper, Lund,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Helsingborg,Department of Clinical Sciences, Lund,Center for cardiac arrest,Lund University Research Groups
-
visa färre...
-
(creator_code:org_t)
- 2022-09-08
- 2022
- Engelska.
-
Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 12:9
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Introduction It is standard of care to provide sedation to critically ill patients to reduce anxiety, discomfort and promote tolerance of mechanical ventilation. Given that sedatives can have differing effects based on a variety of patient and pharmacological characteristics, treatment approaches are largely based on targeting the level of sedation. The benefits of differing levels of sedation must be balanced against potential adverse effects including haemodynamic instability, causing delirium, delaying awakening and prolonging the time of mechanical ventilation and intensive care stay. This systematic review with meta-analysis aims to investigate the current evidence and compare the effects of differing sedation levels in adult critically ill patients. Methods and analyses We will conduct a systematic review based on searches of preidentified major medical databases (eg, MEDLINE, EMBASE, CENTRAL) and clinical trial registries from their inception onwards to identify trials meeting inclusion criteria. We will include randomised clinical trials comparing any degree of sedation with no sedation and lighter sedation with deeper sedation for critically ill patients admitted to the intensive care unit. We will include aggregate data meta-analyses and trial sequential analyses. Risk of bias will be assessed with domains based on the Cochrane risk of bias tool. An eight-step procedure will be used to assess if the thresholds for clinical significance are crossed, and the certainty of the evidence will be assessed using Grades of Recommendations, Assessment, Development and Evaluation. Ethics and dissemination No formal approval or review of ethics is required as individual patient data will not be included. This systematic review has the potential to highlight (1) whether one should believe sedation to be beneficial, harmful or neither in critically ill adults; (2) the existing knowledge gaps and (3) whether the recommendations from guidelines and daily clinical practice are supported by current evidence. These results will be disseminated through publication in a peer-reviewed journal.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Adult anaesthesia
- Adult intensive & critical care
- Anaesthesia in cardiology
- Anaesthesia in neurology
Publikations- och innehållstyp
- for (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
-
BMJ Open
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Ceric, Ameldina
-
Holgersson, Joha ...
-
May, Teresa
-
Skrifvars, Marku ...
-
Hästbacka, Johan ...
-
Saxena, Manoj
-
visa fler...
-
Aneman, Anders
-
Delaney, Anthony
-
Reade, Michael C ...
-
Delcourt, Candic ...
-
Jakobsen, Janus
-
Nielsen, Niklas
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Anestesi och int ...
- Artiklar i publikationen
-
BMJ Open
- Av lärosätet
-
Lunds universitet