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Natural flavonoids ...
Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer : A signature step hinting towards clinical perfection
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- Tuli, Hardeep Singh (författare)
- Maharishi Markandeshwar Engineering College
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- Garg, Vivek Kumar (författare)
- Institute of Nano Science and Technology, Mohali
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Bhushan, Sakshi (författare)
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- Uttam, Vivek (författare)
- Central University of Punjab, India
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- Sharma, Uttam (författare)
- Central University of Punjab, India
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Jain, Aklank (författare)
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Sak, Katrin (författare)
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- Yadav, Vikas (författare)
- Lund University,Lunds universitet,Experimentell patologi, Malmö,Forskargrupper vid Lunds universitet,Experimental Pathology, Malmö,Lund University Research Groups,Skåne University Hospital
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- Lorenzo, Jose M. (författare)
- University of Vigo
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Dhama, Kuldeep (författare)
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- Behl, Tapan (författare)
- University of Petroleum and Energy Studies
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- Sethi, Gautam (författare)
- National University of Singapore
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
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Ingår i: Translational Oncology. - : Elsevier BV. - 1936-5233. ; 27
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore safer and more effective molecules to combat and/or prevent this dreaded disease. Flavonoids, a class of polyphenols, have exhibited multifaceted implications against several diseases including cancer, without showing significant toxicity towards the normal cells. Shredded pieces of evidence suggest that flavonoids can enhance drug sensitivity and suppress proliferation, metastasis, and angiogenesis of cancer cells by modulating several oncogenic or oncosuppressor microRNAs (miRNAs, miRs). They play pivotal roles in regulation of various biological and pathological processes, including various cancers. In the present review, the structure, chemistry and miR targeting efficacy of quercetin, luteolin, silibinin, genistein, epigallocatechin gallate, and cyanidin against several cancer types are comprehensively discussed. miRs are considered as next-generation medicine of recent times, and their targeting by naturally occurring flavonoids in cancer cells could be deemed as a signature step. We anticipate that our compilations related to miRNA-mediated regulation of cancer cells by flavonoids might catapult the clinical investigations and affirmation in the future.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Anti-proliferation
- Apoptosis
- Cancer
- Flavonoids
- MicroRNAs
- Synergism
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tuli, Hardeep Si ...
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Garg, Vivek Kuma ...
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Bhushan, Sakshi
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Uttam, Vivek
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Sharma, Uttam
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Jain, Aklank
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visa fler...
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Sak, Katrin
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Yadav, Vikas
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Lorenzo, Jose M.
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Dhama, Kuldeep
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Behl, Tapan
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Sethi, Gautam
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Translational On ...
- Av lärosätet
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Lunds universitet