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Midlife Intakes of ...
Midlife Intakes of the Isoflavone Genistein and Soy and the Risk of Late-life Cognitive Impairment : The JPHC Saku Mental Health Study
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- Svensson, Thomas (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital,University of Tokyo,Keio University,Kanagawa University of Human Services
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- Sawada, Norie (författare)
- National Cancer Center Tokyo
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- Mimura, Masaru (författare)
- Keio University
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- Nozaki, Shoko (författare)
- Keio University
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- Shikimoto, Ryo (författare)
- Keio University
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- Tsugane, Shoichiro (författare)
- National Cancer Center Tokyo
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Journal of Epidemiology. - 0917-5040. ; 33:7, s. 342-349
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Background: The number of people with cognitive impairment, including dementia, in the world is steadily increasing. Although the consumption of isoflavones and soy is associated with a reduced risk of cardiovascular disease, it might also be associated with cognitive impairment. The low number of studies investigating the association between soy/isoflavone intake and cognitive function warrant additional research. Methods: The Japan Public Health Center-based prospective (JPHC) Study is a large population-based cohort. Midlife dietary intake of soy and the isoflavone genistein was assessed on two occasions: in the years 1995 and 2000. In 2014–2015, 1,299 participants from Nagano prefecture completed a mental health screening. Of these, a total of 1,036 participants were included in analyses. Logistic regression was used to determine Odds Ratios (OR) and 95% Confidence Intervals (CI) for the association between midlife energy-adjusted genistein and soy food intake and cognitive impairment. Results: There were 392 cases of cognitive impairment (346 cases of MCI and 46 cases of dementia). Compared to the lowest dietary quartile of energy-adjusted genistein intake, the highest quartile was significantly associated with cognitive impairment (OR = 1.51; 95% CI, 1.02–2.24; P for trend = 0.03) in the final multivariable analysis. Conclusion: High midlife intake of the isoflavone genistein is associated with late-life cognitive impairment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- dementia
- general population cohort
- isoflavones
- late-life
- midlife
- mild cognitive impairment
- soy foods
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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