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Risk of a first ven...
Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT)
- Artikel/kapitelEngelska2005
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LIBRIS-ID:oai:lup.lub.lu.se:eee6e995-e5d6-42c9-84c6-8c0159492842
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https://lup.lub.lu.se/record/897059URI
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https://doi.org/10.1111/j.1538-7836.2005.01197.xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background. Reliable risk estimates for venous thrombosis in families with inherited thrombophilia are scarce but necessary for determining optimal screening and treatment policies. Objectives: In the present analysis, we determined the risk of a first venous thrombotic event in carriers of a thrombophilic defect (i.e. antithrombin-, protein C- or protein S deficiency, or factor V Leiden). Patients and methods: The asymptomatic carriers had been tested prior to this study in nine European thrombosis centers because of a symptomatic, carrier in the family, and were followed prospectively for 5.7 years on average between March 1994 and January 2001. Annually, data were recorded on the occurrence of risk situations for venous thrombosis and events (e.g. venous thrombosis, death). Results: Twenty-six of the 575 asymptomatic carriers (4.5%) and seven of the 1118 controls (0.6%) experienced a first deep venous thrombosis or pulmonary embolism during follow-up. Of these events, 58% occurred spontaneously in the carriers compared with 43% in the controls. The incidence of first events was 0.8% per year (95% CI 0.5-1.2) in the carriers compared with 0.1% per year (95% CI 0.0-0.2) in the controls. The highest incidence was associated with antithrombin deficiency or combined defects, and the lowest incidence with factor V Leiden. Conclusions: The incidence of venous events in asymptomatic individuals from thrombophilic families does not exceed the risk of bleeding associated with long-term anticoagulant treatment in the literature (1-3%).
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Conard, J
(författare)
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Fontcuberta, J
(författare)
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Makris, M
(författare)
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Van der Meer, FJM
(författare)
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Pabinger, I
(författare)
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Palareti, G
(författare)
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Preston, FE
(författare)
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Scharrer, I
(författare)
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Souto, JC
(författare)
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Svensson, PeterLund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups(Swepub:lu)medf-psv
(författare)
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Walker, ID
(författare)
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Rosendaal, FR
(författare)
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Klinisk koagulationsmedicin, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Thrombosis and Haemostasis: Elsevier BV3:3, s. 459-4641538-79331538-7836
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Till lärosätets databas
- Av författaren/redakt...
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Vossen, CY
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Conard, J
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Fontcuberta, J
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Makris, M
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Van der Meer, FJ ...
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Pabinger, I
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visa fler...
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Palareti, G
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Preston, FE
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Scharrer, I
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Souto, JC
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Svensson, Peter
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Walker, ID
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Rosendaal, FR
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Journal of Throm ...
- Av lärosätet
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Lunds universitet