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- Falconer, C (författare)
Changes in paraurethral connective tissue at menopause are counteracted by estrogen
- Artikel/kapitelEngelska1996
Förlag, utgivningsår, omfång ...
- 1996
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:efb4e7dd-4778-4065-b2f3-beb62ae8ce98
- https://lup.lub.lu.se/record/efb4e7dd-4778-4065-b2f3-beb62ae8ce98URI
- https://doi.org/10.1016/S0378-5122(96)82010-XDOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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Klassifikation
Anmärkningar
- OBJECTIVE: To study whether the transition to menopause is accompanied by changes in the paraurethral connective tissue and if these changes are modified by estrogen replacement therapy.STUDY DESIGN: Biopsies were obtained from the paraurethral tissue from 34 women; 12 menstruating, 14 postmenopausal without estrogen treatment, and 8 with estrogen treatment. Collagen concentration and collagen extractability by pepsin digestion were measured. Proteoglycan composition and concentration were analysed using Alcian blue. The mRNA levels for collagen I and III, the small proteoglycans (PGS) decorin and biglycan, and the large proteoglycan versican, were estimated.RESULTS: The paraurethral biopsies consisted of fibrous connective tissue, with collagen fibers as dominating structure. Several proteoglycans were identified; versican, heparansulphate proteoglycans, biglycan and decorin. The small proteoglycan decorin represented 85% of all proteoglycans. The collagen concentration was almost doubled in postmenopausal biopsies compared to premenopausal. The collagen fibril organization was also changed with higher cross-linking after menopause whereas the amount and the composition of the proteoglycans were unchanged. The proteoglycan/collagen ratio was significantly decreased. Estrogen replacement therapy resulted in decreased collagen concentration, decreased cross-linking of the collagen and reversal of the PGS/collagen ratio to almost premenopausal level. The therapy resulted in increased levels of mRNA for collagen I and III which suggests that the changes are due to an increased turnover.CONCLUSION: The decrease in estrogen levels at menopause results in a connective tissue with different qualities after menopause. Estrogen replacement therapy tends to restore the metabolism of the genitourinary connective tissue to premenopausal conditions.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- Adult
- Aged
- Alcian Blue
- Biglycan
- Biopsy
- Chondroitin Sulfate Proteoglycans
- Collagen
- Coloring Agents
- Connective Tissue
- Decorin
- Dermatan Sulfate
- Estrogen Replacement Therapy
- Estrogens
- Extracellular Matrix Proteins
- Female
- Heparitin Sulfate
- Humans
- Lectins
- Lectins, C-Type
- Menopause
- Menstruation
- Middle Aged
- Pepsin A
- Postmenopause
- Premenopause
- Proteoglycans
- RNA, Messenger
- Urethra
- Versicans
- Comparative Study
- Journal Article
- Research Support, Non-U.S. Gov't
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Ekman-Ordeberg, G (författare)
- Ulmsten, U (författare)
- Westergren-Thorsson, GLund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups(Swepub:lu)medk-gwt (författare)
- Barchan, K (författare)
- Malmström, ALund University,Lunds universitet,Matrixbiologi,Forskargrupper vid Lunds universitet,Matrix Biology,Lund University Research Groups(Swepub:lu)medk-ama (författare)
- LungbiologiForskargrupper vid Lunds universitet (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Maturitas24:3, s. 197-2040378-5122
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