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Tuberculosis Infect...
Tuberculosis Infection in Women of Reproductive Age : A Cross-sectional Study at Antenatal Care Clinics in an Ethiopian City
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- Walles, John (författare)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Central Hospital Kristianstad
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- Tesfaye, Fregenet (författare)
- Armauer Hansen Research Institute
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- Jansson, Marianne (författare)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
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- Balcha, Taye Tolera (författare)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups
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- Sturegård, Erik (författare)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Klinisk infektionsmedicin,Clinical Microbiology, Malmö,Lund University Research Groups,Clinical infection medicine
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Kefeni, Mestawet (författare)
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- Merga, Gadissa (författare)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups
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- Hansson, Stefan R. (författare)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för translationell obstetrisk forskning,Forskargrupper vid Lunds universitet,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for translational obstetric research,Lund University Research Groups
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- Winqvist, Niclas (författare)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups
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- Björkman, Per (författare)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2020-05-15
- 2021
- Engelska 8 s.
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Ingår i: Clinical Infectious Diseases. - : Oxford University Press (OUP). - 1058-4838 .- 1537-6591. ; 73:2, s. 203-210
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http://dx.doi.org/10... (free)
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https://academic.oup...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Knowledge on tuberculosis (TB) infection epidemiology in women of reproductive age living in TB-endemic areas is limited. We used a composite definition of TB infection in a cohort of pregnant women recruited in an Ethiopian city as a model for TB exposure patterns, and to identify factors associated with TB infection. Methods: Women seeking antenatal care at public health facilities underwent structured interviews, physical examination, and QuantiFERON-TB Gold-Plus (QFT) testing. Women with symptoms compatible with TB disease, and all human immunodeficiency virus (HIV)-positive women, were investigated for active TB by sputum bacteriological testing. TB infection (TB+) was defined as either positive QFT (≥ 0.35 IU/mL), self-reported previous active TB, or current active TB. Associations between TB infection and clinical, demographic, and socioeconomic characteristics were tested in multiple logistic regression analysis. Results: Among 1834 participants, 679 (37.0%) met criteria for TB+ (80 [4.4%] previous active TB, 5 [0.3%] current active TB, and 594 [32.4%] QFT-positive without previous or current active TB). Age (annual adjusted odds ratio [AOR], 1.069 [95% confidence interval {CI}, 1.045-1.093]) and HIV infection (AOR, 1.43 [95% CI, 1.033-1.988]) were independently associated with TB+. The relationship with increasing age was only observed in HIV-negative women, and translated to an estimated annual risk of TB infection of 2.1% in HIV-negative women. Conclusions: TB infection in women of reproductive age in Ethiopia was independently associated with HIV infection and increasing age, suggesting exposure to contagious TB and continuous acquisition of TB infection in this population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Ethiopia
- HIV
- pregnancy
- QuantiFERON
- tuberculosis
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Walles, John
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Tesfaye, Fregene ...
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Jansson, Mariann ...
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Balcha, Taye Tol ...
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Sturegård, Erik
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Kefeni, Mestawet
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Merga, Gadissa
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Hansson, Stefan ...
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Winqvist, Niclas
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Björkman, Per
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- MEDICIN OCH HÄLSOVETENSKAP
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Clinical Infecti ...
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Lunds universitet