SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:f0c2b346-a12a-47f0-827f-2c468074e178"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:f0c2b346-a12a-47f0-827f-2c468074e178" > Adult-onset type 1 ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004603naa a2200529 4500
001oai:lup.lub.lu.se:f0c2b346-a12a-47f0-827f-2c468074e178
003SwePub
008200717s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/f0c2b346-a12a-47f0-827f-2c468074e1782 URI
0247 a https://doi.org/10.1002/dmrr.33572 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ren, Wenqianu Third Affiliated Hospital of Sun Yat‐sen University4 aut
2451 0a Adult-onset type 1 diabetic patients with less severe clinical manifestation have less risk DR-DQ genotypes than childhood-onset patients
264 c 2020-06-21
264 1b Wiley,c 2021
520 a Background: The aim of this study was to investigate differences in clinical features and HLA genotypes between adult-onset and childhood-onset patients with type 1 diabetes in a Chinese population. Materials and Methods: This study enrolled 716 Han Chinese patients with type 1 diabetes from Guangdong (258 childhood-onset and 458 adult-onset) to compare their clinical features. Of them 214 patients with classical type 1 diabetes (100 childhood-onset and 114 adult-onset) were selected for HLA DR and DQ genotyping by next-generation sequencing. Results: Adult-onset patients were characterized by longer duration of symptoms before diagnosis, lower frequency of DKA at disease onset, less frequent autoantibody positivity, higher serum C-peptide concentrations, and better glycemic control. These findings were replicated in the restricted cohort of 214 patients with classical type 1 diabetes. Compared with childhood-onset patients, adult-onset patients had a lower frequency of the DR9 haplotype, as well as lower frequency of high-risk DR3/DR4 and DR3/DR9 genotypes, but higher frequency of DR3/DR3 genotype and DR3/X, DR4/X or DR9/X (X, non-risk) genotypes. Conclusions: Adult-onset type 1 diabetic patients with susceptible haplotypes (DR3, DR4 or DR9) were more likely to carry protective DR-DQ haplotypes than childhood-onset patients, which suggested the association between less risk DR-DQ genotypes and the less severe clinical manifestation in adult-onset patients.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a adult onset diabetes
653 a age of diabetes onset
653 a clinical characteristics
653 a genetics
653 a HLA typing
653 a type 1 diabetes
7001 a Yang, Daizhiu Third Affiliated Hospital of Sun Yat‐sen University4 aut
7001 a Jiang, Ziyuu Third Affiliated Hospital of Sun Yat‐sen University4 aut
7001 a Xian, Yingxinu Third Affiliated Hospital of Sun Yat‐sen University4 aut
7001 a Huang, Qianwenu Third Affiliated Hospital of Sun Yat‐sen University4 aut
7001 a Luo, Sihuiu Third Affiliated Hospital of Sun Yat‐sen University,University of Science and Technology of China4 aut
7001 a Zheng, Xueyingu University of Science and Technology of China4 aut
7001 a Yan, Jinhuau Third Affiliated Hospital of Sun Yat‐sen University4 aut
7001 a Xu, Wenu Third Affiliated Hospital of Sun Yat‐sen University4 aut
7001 a Yao, Binu Third Affiliated Hospital of Sun Yat‐sen University4 aut
7001 a Wang, Cong Yiu Huazhong University of Science and Technology4 aut
7001 a Bei, Jin Xinu Sun Yat-sen University4 aut
7001 a Groop, Leifu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Science and Technology of China,Skåne University Hospital4 aut0 (Swepub:lu)endo-lgr
7001 a Noble, Janelle A.u Children's Hospital Oakland Research Institute4 aut
7001 a Weng, Jianpingu University of Science and Technology of China,Third Affiliated Hospital of Sun Yat‐sen University4 aut
7102 a Third Affiliated Hospital of Sun Yat‐sen Universityb University of Science and Technology of China4 org
7730 t Diabetes/Metabolism Research and Reviewsd : Wileyg 37:1q 37:1x 1520-7552x 1520-7560
8564 u http://dx.doi.org/10.1002/dmrr.3357x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/f0c2b346-a12a-47f0-827f-2c468074e178
8564 8u https://doi.org/10.1002/dmrr.3357

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy