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Mutation and gender...
Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome
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Migdalovich, Dimitry (författare)
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Moss, Arthur J. (författare)
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Lopes, Coeli M. (författare)
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Costa, Jason (författare)
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Ouellet, Gregory (författare)
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Barsheshet, Alon (författare)
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McNitt, Scott (författare)
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Polonsky, Slava (författare)
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Robinson, Jennifer L. (författare)
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Zareba, Wojciech (författare)
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Ackerman, Michael J. (författare)
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Benhorin, Jesaia (författare)
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Kaufman, Elizabeth S. (författare)
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- Platonov, Pyotr (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Shimizu, Wataru (författare)
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Towbin, Jeffrey A. (författare)
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Vincent, G. Michael (författare)
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Wilde, Arthur A. M. (författare)
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Goldenberg, Ilan (författare)
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
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Ingår i: Heart Rhythm. - : Elsevier BV. - 1547-5271. ; 8:10, s. 1537-1543
- Relaterad länk:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND Men and women with type 2 long QT syndrome (LQT2) exhibit time-dependent differences in the risk for cardiac events. We hypothesized that data regarding the location of the disease-causing mutation in the KCNH2 channel may affect gender-specific risk in LQT2. OBJECTIVE This study sought to risk-stratify LQT2 patients for life-threatening cardiac events based on clinical and genetic information. METHODS The risk for life-threatening cardiac events from birth through age 40 years (comprising aborted cardiac arrest [ACA] or sudden cardiac death [SCD]) was assessed among 1,166 LQT2 male (n = 490) and female (n = 676) patients by the location of the LQTS-causing mutation in the KCNH2 channel (prespecified in the primary analysis as pore-loop vs. non-pore-loop). RESULTS During follow-up, the cumulative probability of life-threatening cardiac events years was significantly higher among LQT2 women (26%) as compared with men (14%; P <.001). Multivariate analysis showed that the risk for life-threatening cardiac events was not significantly different between women with and without pore-loop mutations (hazard ratio 1.20; P = .33). In contrast, men with pore-loop mutations displayed a significant > 2-fold higher risk of a first ACA or SCD as compared with those with non-pore-loop mutations (hazard ratio 2.18; P = .01). Consistently, women experienced a high rate of life-threatening events regardless of mutation location (pore-loop: 35%, nonpore-loop: 23%), whereas in men the rate of ACA or SCD was high among those with pore-loop mutations (28%) and relatively low among those with non-pore-loop mutations (8%). CONCLUSION Combined assessment of clinical and mutation-specific data can be used for improved risk stratification for life-threatening cardiac events in LQT2.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Long QT syndrome
- Pore-loop mutations
- Sudden cardiac death
- Gender
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Migdalovich, Dim ...
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Moss, Arthur J.
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Lopes, Coeli M.
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Costa, Jason
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Ouellet, Gregory
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Barsheshet, Alon
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visa fler...
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McNitt, Scott
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Polonsky, Slava
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Robinson, Jennif ...
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Zareba, Wojciech
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Ackerman, Michae ...
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Benhorin, Jesaia
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Kaufman, Elizabe ...
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Platonov, Pyotr
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Shimizu, Wataru
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Towbin, Jeffrey ...
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Vincent, G. Mich ...
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Wilde, Arthur A. ...
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Goldenberg, Ilan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Heart Rhythm
- Av lärosätet
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Lunds universitet