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Lung Inflammatory E...
Lung Inflammatory Environments Differentially Alter Mesenchymal Stromal Cell Behavior
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- Abreu, Soraia Carvalho (författare)
- University of Vermont
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- Enes, Sara Rolandsson (författare)
- Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups,University of Vermont
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- Dearborn, Jacob (författare)
- University of Vermont
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- Goodwin, Meagan (författare)
- University of Vermont
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- Coffey, Amy (författare)
- University of Vermont
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- Borg, Zachary D (författare)
- University of Vermont
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- Dos Santos, Claudia C (författare)
- University of Toronto
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- Wargo, Matthew J (författare)
- University of Vermont
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- Cruz, Fernanda Ferreira (författare)
- Federal University of Rio de Janeiro
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- Loi, Roberto (författare)
- University of Cagliari
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- DeSarno, Michael (författare)
- University of Vermont
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- Ashikaga, Takamaru (författare)
- University of Vermont
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- Antunes, Mariana Alves (författare)
- Federal University of Rio de Janeiro
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- Rocco, Patricia R M (författare)
- Federal University of Rio de Janeiro
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- Liu, Kathleen D (författare)
- University of California, San Francisco
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- Lee, Jae-Woo (författare)
- University of California, San Francisco
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- Matthay, Michael A (författare)
- University of California, San Francisco
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- McKenna, D H (författare)
- University of Minnesota
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- Weiss, Daniel J (författare)
- University of Vermont
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(creator_code:org_t)
- American Physiological Society, 2019
- 2019
- Engelska 9 s.
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Ingår i: American Journal of Physiology: Lung Cellular and Molecular Physiology. - : American Physiological Society. - 1522-1504 .- 1040-0605. ; 317:6, s. 823-831
- Relaterad länk:
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http://dx.doi.org/10...
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https://journals.phy...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Mesenchymal stromal (stem) cells (MSCs) are increasingly demonstrated to ameliorate experimentally-induced lung injuries through disease-specific anti-inflammatory actions, thus suggesting that different in vivo inflammatory environments can influence MSC actions. To determine the effects of different representative inflammatory lung conditions, human bone marrow-derived MSCs (hMSCs) were exposed to in vitro culture conditions from bronchoalveolar lavage fluid (BALF) samples obtained from patients with either the acute respiratory distress syndrome (ARDS) or with other lung diseases including acute respiratory exacerbations of cystic fibrosis (CF) (non-ARDS). hMSCs were subsequently assessed for time- and BALF concentration-dependent effects on mRNA expression of selected pro- and anti-inflammatory mediators, and for overall patterns of gene and mRNA expression. Both common and disease specific-patterns were observed in gene expression of different hMSC mediators, notably interleukin (IL)-6. Conditioned media obtained from non-ARDS BALF-exposed hMSCs was more effective in promoting an anti-inflammatory phenotype in monocytes than was conditioned media from ARDS BALF-exposed hMSCs. Neutralizing IL-6 in the conditioned media promoted generation of anti-inflammatory monocyte phenotype. These results demonstrated that different lung inflammatory environments differentially alter hMSC behavior. Further identification of these interactions and the driving mechanisms may influence clinical use of MSCs for treating lung diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Abreu, Soraia Ca ...
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Enes, Sara Rolan ...
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Dearborn, Jacob
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Goodwin, Meagan
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Coffey, Amy
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Borg, Zachary D
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visa fler...
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Dos Santos, Clau ...
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Wargo, Matthew J
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Cruz, Fernanda F ...
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Loi, Roberto
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DeSarno, Michael
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Ashikaga, Takama ...
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Antunes, Mariana ...
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Rocco, Patricia ...
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Liu, Kathleen D
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Lee, Jae-Woo
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Matthay, Michael ...
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McKenna, D H
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Weiss, Daniel J
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Mikrobiologi ino ...
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American Journal ...
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Lunds universitet