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Dynamic 2D and 3D m...
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Müller, Christoph A.Albert-Ludwigs University Freiburg,German Cancer Research Centre
(författare)
Dynamic 2D and 3D mapping of hyperpolarized pyruvate to lactate conversion in vivo with efficient multi-echo balanced steady-state free precession at 3 T
- Artikel/kapitelEngelska2020
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:f2c503df-d354-4dd1-b974-be514b1a9977
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https://lup.lub.lu.se/record/f2c503df-d354-4dd1-b974-be514b1a9977URI
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https://doi.org/10.1002/nbm.4291DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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The aim of this study was to acquire the transient MRI signal of hyperpolarized tracers and their metabolites efficiently, for which specialized imaging sequences are required. In this work, a multi-echo balanced steady-state free precession (me-bSSFP) sequence with Iterative Decomposition with Echo Asymmetry and Least squares estimation (IDEAL) reconstruction was implemented on a clinical 3 T positron-emission tomography/MRI system for fast 2D and 3D metabolic imaging. Simulations were conducted to obtain signal-efficient sequence protocols for the metabolic imaging of hyperpolarized biomolecules. The sequence was applied in vitro and in vivo for probing the enzymatic exchange of hyperpolarized [1–13C]pyruvate and [1–13C]lactate. Chemical shift resolution was achieved using a least-square, iterative chemical species separation algorithm in the reconstruction. In vitro, metabolic conversion rate measurements from me-bSSFP were compared with NMR spectroscopy and free induction decay-chemical shift imaging (FID-CSI). In vivo, a rat MAT-B-III tumor model was imaged with me-bSSFP and FID-CSI. 2D metabolite maps of [1–13C]pyruvate and [1–13C]lactate acquired with me-bSSFP showed the same spatial distributions as FID-CSI. The pyruvate-lactate conversion kinetics measured with me-bSSFP and NMR corresponded well. Dynamic 2D metabolite mapping with me-bSSFP enabled the acquisition of up to 420 time frames (scan time: 180-350 ms/frame) before the hyperpolarized [1–13C]pyruvate was relaxed below noise level. 3D metabolite mapping with a large field of view (180 × 180 × 48 mm3) and high spatial resolution (5.6 × 5.6 × 2 mm3) was conducted with me-bSSFP in a scan time of 8.2 seconds. It was concluded that Me-bSSFP improves the spatial and temporal resolution for metabolic imaging of hyperpolarized [1–13C]pyruvate and [1–13C]lactate compared with either of the FID-CSI or EPSI methods reported at 3 T, providing new possibilities for clinical and preclinical applications.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hundshammer, ChristianKlinikum rechts der Isar
(författare)
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Braeuer, MiriamKlinikum rechts der Isar
(författare)
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Skinner, Jason G.Klinikum rechts der Isar,Albert-Ludwigs University Freiburg
(författare)
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Berner, StephanGerman Cancer Research Centre,Albert-Ludwigs University Freiburg
(författare)
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Leupold, JochenAlbert-Ludwigs University Freiburg
(författare)
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Düwel, StephanKlinikum rechts der Isar
(författare)
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Nekolla, Stephan G.Klinikum rechts der Isar
(författare)
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Månsson, SvenLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)ront-sma
(författare)
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Hansen, Adam E.University of Copenhagen
(författare)
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von Elverfeldt, DominikAlbert-Ludwigs University Freiburg
(författare)
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Ardenkjaer-Larsen, Jan H.Technical University of Denmark
(författare)
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Schilling, FranzKlinikum rechts der Isar
(författare)
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Schwaiger, MarkusKlinikum rechts der Isar
(författare)
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Hennig, JürgenAlbert-Ludwigs University Freiburg
(författare)
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Hövener, Jan BerndAlbert-Ludwigs University Freiburg,University Medical Center Schleswig-Holstein
(författare)
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Albert-Ludwigs University FreiburgGerman Cancer Research Centre
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:NMR in Biomedicine: Wiley33:60952-34801099-1492
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Müller, Christop ...
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Hundshammer, Chr ...
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Braeuer, Miriam
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Skinner, Jason G ...
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Berner, Stephan
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Leupold, Jochen
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Düwel, Stephan
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Nekolla, Stephan ...
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Månsson, Sven
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Hansen, Adam E.
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von Elverfeldt, ...
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Ardenkjaer-Larse ...
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Schilling, Franz
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Schwaiger, Marku ...
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Hennig, Jürgen
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Hövener, Jan Ber ...
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