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Long-COVID fatigue ...
Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19
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- Freidin, Maxim B. (författare)
- Queen Mary University,King's College London
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- Cheetham, Nathan (författare)
- King's College London
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- Duncan, Emma L. (författare)
- King's College London
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- Steves, Claire J. (författare)
- King's College London
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- Doores, Katherine J. (författare)
- King's College London
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- Malim, Michael H. (författare)
- King's College London
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- Rossi, Niccolo (författare)
- King's College London
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Lord, Janet M. (författare)
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- Franks, Paul W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Borsini, Alessandra (författare)
- King's College London
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- Granville Smith, Isabelle (författare)
- King's College London
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- Falchi, Mario (författare)
- King's College London
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- Pariante, Carmine (författare)
- King's College London
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- Williams, Frances M.K. (författare)
- King's College London
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Inflammation Research. - 1023-3830. ; 72:5, s. 947-953
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective and design: Fatigue is a prominent symptom in the general population and may follow viral infection, including SARS-CoV2 infection which causes COVID-19. Chronic fatigue lasting more than three months is the major symptom of the post-COVID syndrome (known colloquially as long-COVID). The mechanisms underlying long-COVID fatigue are unknown. We hypothesized that the development of long-COVID chronic fatigue is driven by the pro-inflammatory immune status of an individual prior to COVID-19. Subjects and methods: We analyzed pre-pandemic plasma levels of IL-6, which plays a key role in persistent fatigue, in N = 1274 community dwelling adults from TwinsUK. Subsequent COVID-19-positive and -negative participants were categorized based on SARS-CoV-2 antigen and antibody testing. Chronic fatigue was assessed using the Chalder Fatigue Scale. Results: COVID-19-positive participants exhibited mild disease. Chronic fatigue was a prevalent symptom among this population and significantly higher in positive vs. negative participants (17% vs 11%, respectively; p = 0.001). The qualitative nature of chronic fatigue as determined by individual questionnaire responses was similar in positive and negative participants. Pre-pandemic plasma IL-6 levels were positively associated with chronic fatigue in negative, but not positive individuals. Raised BMI was associated with chronic fatigue in positive participants. Conclusions: Pre-existing increased IL-6 levels may contribute to chronic fatigue symptoms, but there was no increased risk in individuals with mild COVID-19 compared with uninfected individuals. Elevated BMI also increased the risk of chronic fatigue in mild COVID-19, consistent with previous reports.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- BMI
- Chronic fatigue
- IL-6
- Inflammation
- Long-COVID
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Freidin, Maxim B ...
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Cheetham, Nathan
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Duncan, Emma L.
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Steves, Claire J ...
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Doores, Katherin ...
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Malim, Michael H ...
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visa fler...
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Rossi, Niccolo
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Lord, Janet M.
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Franks, Paul W.
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Borsini, Alessan ...
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Granville Smith, ...
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Falchi, Mario
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Pariante, Carmin ...
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Williams, France ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
- Artiklar i publikationen
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Inflammation Res ...
- Av lärosätet
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Lunds universitet