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Multi-centre evalua...
Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification : An IAEA phantom study
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- Zimmerman, Brian E (författare)
- National Institute of Standards and Technology (NIST)
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- Grošev, Darko (författare)
- University Hospital Centre Zagreb
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- Buvat, Irène (författare)
- Service Hospitalier Frédéric Joliot
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- Coca Pérez, Marco A (författare)
- Medscan Concepción
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- Frey, Eric C (författare)
- Johns Hopkins University
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- Green, Alan (författare)
- National Physical Laboratory, UK
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- Krisanachinda, Anchali (författare)
- Chulalongkorn University
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- Lassmann, Michael (författare)
- Julius Maximilian University of Würzburg
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- Ljungberg, Michael (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nuclear Medicine Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Pozzo, Lorena (författare)
- Institute of Energy and Nuclear Research, Brazil
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- Quadir, Kamila Afroj (författare)
- National Institute of Nuclear Medicine & Allied Sciences, Dhaka, Bangladesh.
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- Terán Gretter, Mariella A (författare)
- University of the Republic
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- Van Staden, Johann (författare)
- University of the Free State
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- Poli, Gian Luca (författare)
- International Atomic Energy Agency (IAEA)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska 15 s.
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Ingår i: Zeitschrift für Medizinische Physik. - : Elsevier BV. - 1876-4436 .- 0939-3889. ; 27:2, s. 98-112
- Relaterad länk:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Accurate quantitation of activity provides the basis for internal dosimetry of targeted radionuclide therapies. This study investigated quantitative imaging capabilities at sites with a variety of experience and equipment and assessed levels of errors in activity quantitation in Single-Photon Emission Computed Tomography (SPECT) and planar imaging. Participants from 9 countries took part in a comparison in which planar, SPECT and SPECT with X ray computed tomography (SPECT-CT) imaging were used to quantify activities of four epoxy-filled cylinders containing 133Ba, which was chosen as a surrogate for 131I. The sources, with nominal volumes of 2, 4, 6 and 23mL, were calibrated for 133Ba activity by the National Institute of Standards and Technology, but the activity was initially unknown to the participants. Imaging was performed in a cylindrical phantom filled with water. Two trials were carried out in which the participants first estimated the activities using their local standard protocols, and then repeated the measurements using a standardized acquisition and analysis protocol. Finally, processing of the imaging data from the second trial was repeated by a single centre using a fixed protocol. In the first trial, the activities were underestimated by about 15% with planar imaging. SPECT with Chang's first order attenuation correction (Chang-AC) and SPECT-CT overestimated the activity by about 10%. The second trial showed moderate improvements in accuracy and variability. Planar imaging was subject to methodological errors, e.g., in the use of a transmission scan for attenuation correction. The use of Chang-AC was subject to variability from the definition of phantom contours. The project demonstrated the need for training and standardized protocols to achieve good levels of quantitative accuracy and precision in a multicentre setting. Absolute quantification of simple objects with no background was possible with the strictest protocol to about 6% with planar imaging and SPECT (with Chang-AC) and within 2% for SPECT-CT.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- Humans
- Image Processing, Computer-Assisted
- Phantoms, Imaging/standards
- Radiometry
- Reproducibility of Results
- Tomography, Emission-Computed, Single-Photon/methods
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zimmerman, Brian ...
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Grošev, Darko
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Buvat, Irène
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Coca Pérez, Marc ...
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Frey, Eric C
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Green, Alan
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Krisanachinda, A ...
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Lassmann, Michae ...
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Ljungberg, Micha ...
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Pozzo, Lorena
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Quadir, Kamila A ...
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Terán Gretter, M ...
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Van Staden, Joha ...
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Poli, Gian Luca
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- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Medicinteknik
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och Medicinsk labora ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Fysik
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och Annan fysik
- Artiklar i publikationen
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Zeitschrift für ...
- Av lärosätet
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Lunds universitet