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Human achaete-scute...
Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells
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- Söderholm, Helena, 1969- (författare)
- Uppsala universitet,Institutionen för patologi,Sven Påhlman
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- Örtoft, Eva (författare)
- Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, Malmö, Sweden
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- Johansson, Irja (författare)
- Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, Malmö, Sweden
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- Ljungberg, June (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, Malmö, Sweden
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- Larsson, Christer (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, Malmö, Sweden
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- Axelson, Håkan (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, Malmö, Sweden
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- Påhlman, Sven (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, Malmö, Sweden
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(creator_code:org_t)
- Elsevier BV, 1999
- 1999
- Engelska.
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Ingår i: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 256:3, s. 557-563
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The mammalian achaete-scute homologue, MASH-1, is crucial for early development of the sympathetic nervous system and is transiently expressed in sympathetic neuroblasts during embryogenesis. Here we report that the human homologue (HASH-1) was expressed in all analyzed cell lines (6/6) derived from the sympathetic nervous system tumor neuroblastoma. The majority of small-cell lung carcinoma (4/5) cell lines tested expressed HASH-1, while other nonneuronal/non-neuroendocrine cell lines were negative. Induced differentiation of neuroblastoma cells resulted in HASH-1 downregulation. This occurred concomitant with induction of neurite outgrowth and expression of the neuronal marker genes GAP-43 and neuropeptide Y. Constitutive expression of exogenous HASH-1 did not alter the capacity of the neuroblastoma cells to differentiate in response to differentiation-inducing agents. It is concluded that moderate HASH-1 expression does not compromise the capacity of these cells to differentiate.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
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- ref (ämneskategori)
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