Sökning: onr:"swepub:oai:lup.lub.lu.se:f9814373-6038-4802-be1f-18f305cf9c19" > Subtype and cell ty...
Fältnamn | Indikatorer | Metadata |
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000 | 04915naa a2200481 4500 | |
001 | oai:lup.lub.lu.se:f9814373-6038-4802-be1f-18f305cf9c19 | |
003 | SwePub | |
008 | 221020s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/f9814373-6038-4802-be1f-18f305cf9c192 URI |
024 | 7 | a https://doi.org/10.1038/s42003-022-03559-72 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Bjørklund, Sunniva Stordalu Norwegian Radium Hospital,Oslo university hospital4 aut |
245 | 1 0 | a Subtype and cell type specific expression of lncRNAs provide insight into breast cancer |
264 | c 2022-08-18 | |
264 | 1 | b Springer Science and Business Media LLC,c 2022 |
520 | a Long non-coding RNAs (lncRNAs) are involved in breast cancer pathogenesis through chromatin remodeling, transcriptional and post-transcriptional gene regulation. We report robust associations between lncRNA expression and breast cancer clinicopathological features in two population-based cohorts: SCAN-B and TCGA. Using co-expression analysis of lncRNAs with protein coding genes, we discovered three distinct clusters of lncRNAs. In silico cell type deconvolution coupled with single-cell RNA-seq analyses revealed that these three clusters were driven by cell type specific expression of lncRNAs. In one cluster lncRNAs were expressed by cancer cells and were mostly associated with the estrogen signaling pathways. In the two other clusters, lncRNAs were expressed either by immune cells or fibroblasts of the tumor microenvironment. To further investigate the cis-regulatory regions driving lncRNA expression in breast cancer, we identified subtype-specific transcription factor (TF) occupancy at lncRNA promoters. We also integrated lncRNA expression with DNA methylation data to identify long-range regulatory regions for lncRNA which were validated using ChiA-Pet-Pol2 loops. lncRNAs play an important role in shaping the gene regulatory landscape in breast cancer. We provide a detailed subtype and cell type-specific expression of lncRNA, which improves the understanding of underlying transcriptional regulation in breast cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Aure, Miriam Ragleu Norwegian Radium Hospital,Oslo university hospital4 aut |
700 | 1 | a Häkkinen, Jariu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)thep-jha |
700 | 1 | a Vallon-Christersson, Johanu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)onk-jvc |
700 | 1 | a Kumar, Surendrau Norwegian Radium Hospital,Memorial University of Newfoundland4 aut |
700 | 1 | a Evensen, Katrine Bullu Norwegian Radium Hospital4 aut |
700 | 1 | a Fleischer, Thomasu Norwegian Radium Hospital4 aut |
700 | 1 | a Tost, Jörgu University of Paris-Saclay4 aut |
700 | 1 | a Sahlberg, Kristine K.u Norwegian Radium Hospital,Oslo university hospital4 aut |
700 | 1 | a Mathelier, Anthonyu University of Oslo,Oslo university hospital4 aut |
700 | 1 | a Bhanot, Gyanu Rutgers University: The State University of New Jersey,Rutgers Cancer Institute of New Jersey4 aut |
700 | 1 | a Ganesan, Shridaru Rutgers Cancer Institute of New Jersey4 aut |
700 | 1 | a Tekpli, Xavieru Norwegian Radium Hospital,Oslo university hospital4 aut |
700 | 1 | a Kristensen, Vessela N.u Oslo university hospital,University of Oslo4 aut |
710 | 2 | a Norwegian Radium Hospitalb Oslo university hospital4 org |
710 | 2 | a OSBREAC |
773 | 0 | t Communications Biologyd : Springer Science and Business Media LLCg 5:1q 5:1x 2399-3642 |
856 | 4 | u http://dx.doi.org/10.1038/s42003-022-03559-7x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/f9814373-6038-4802-be1f-18f305cf9c19 |
856 | 4 8 | u https://doi.org/10.1038/s42003-022-03559-7 |
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