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Genetic Polymorphis...
Genetic Polymorphisms in Host Innate Immune Sensor Genes and the Risk of Nasopharyngeal Carcinoma in North Africa
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Moumad, Khalid (författare)
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Lascorz, Jesus (författare)
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Bevier, Melanie (författare)
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Khyatti, Meriem (författare)
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Ennaji, Moulay Mustapha (författare)
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Benider, Abdellatif (författare)
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Huhn, Stefanie (författare)
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Lu, Shun (författare)
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Chouchane, Lotfi (författare)
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Corbex, Marilys (författare)
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- Hemminki, Kari (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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- Försti, Asta (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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visa färre...
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(creator_code:org_t)
- 2013-06-01
- 2013
- Engelska.
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Ingår i: G3: Genes, Genomes, Genetics. - : Oxford University Press (OUP). - 2160-1836. ; 3:6, s. 971-977
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world. It is an Epstein-Barr virus-associated malignancy with an unusual racial and geographical distribution. The host innate immune sensor genes play an important role in infection recognition and immune response against viruses. Therefore, we examined the association between polymorphisms in genes within a group of pattern recognition receptors (including families of Toll-like receptors, C-type lectin receptors, and retinoic acid-inducible gene I-like receptors) and NPC susceptibility. Twenty-six single-nucleotide polymorphisms (SNPs) in five pattern-recognition genes were genotyped in 492 North African NPC cases and 373 frequency-matched controls. TLR3_rs3775291 was the most significantly associated SNP (odds ratio [OR] 1.49; 95% confidence interval [95% CI] 1.11-2.00; P = 0.008; dominant model). The analysis showed also that CD209_rs7248637 (OR 0.69; 95% CI 0.52-0.93; P = 0.02; dominant model) and DDX58_rs56309110 (OR 0.70; 95% CI 0.51-0.98; P = 0.04) were associated with the risk of NPC. An 18% increased risk per allele was observed for the five most significantly associated SNPs, TLR3_rs3775291, CD209_rs7248637, DDX58_rs56309110, CD209_rs4804800, and MBL2_rs10824792, (p(trend) = 8.2 x 10(-4)). Our results suggest that genetic variation in pattern-recognition genes is associated with the risk of NPC. These preliminary findings require replication in larger studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- nasopharyngeal carcinoma
- North Africa
- host innate immune sensors
- SNPs
- Epstein-Barr virus
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Moumad, Khalid
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Lascorz, Jesus
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Bevier, Melanie
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Khyatti, Meriem
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Ennaji, Moulay M ...
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Benider, Abdella ...
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visa fler...
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Huhn, Stefanie
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Lu, Shun
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Chouchane, Lotfi
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Corbex, Marilys
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Hemminki, Kari
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Försti, Asta
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visa färre...
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Lunds universitet