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Assessment of preci...
Assessment of precision and accuracy of brain white matter microstructure using combined diffusion MRI and relaxometry
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- Coelho, Santiago (författare)
- NYU Grossman School of Medicine
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- Liao, Ying (författare)
- NYU Grossman School of Medicine
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- Szczepankiewicz, Filip (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Multidimensional microstructure imaging,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Veraart, Jelle (författare)
- NYU Grossman School of Medicine
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- Chung, Sohae (författare)
- NYU Grossman School of Medicine
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- Lui, Yvonne W. (författare)
- NYU Grossman School of Medicine
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- Novikov, Dmitry S. (författare)
- NYU Grossman School of Medicine
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- Fieremans, Els (författare)
- NYU Grossman School of Medicine
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Human Brain Mapping. - 1065-9471. ; 45:9
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Joint modeling of diffusion and relaxation has seen growing interest due to its potential to provide complementary information about tissue microstructure. For brain white matter (WM), we designed an optimal diffusion-relaxometry MRI protocol that samples multiple b-values, B-tensor shapes, and echo times (TE). This variable-TE protocol (27 min) has as subsets a fixed-TE protocol (15 min) and a two-shell dMRI protocol (7 min), both characterizing diffusion only. We assessed the sensitivity, specificity, and reproducibility of these protocols with synthetic experiments and in six healthy volunteers. Compared with the fixed-TE protocol, the variable-TE protocol enables estimation of the free water fraction while also capturing compartmental (Formula presented.) relaxation times. Jointly measuring diffusion and relaxation offers increased sensitivity and specificity to microstructure parameters in brain WM with voxelwise coefficients of variation below 10%.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
Nyckelord
- biophysical modeling
- brain white matter
- diffusion-relaxometry
- microstructure imaging
- multidimensional diffusion MRI
- protocol optimization
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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