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Attenuated early pr...
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Redman, Leanne M.Pennington Biomedical Research Center
(författare)
Attenuated early pregnancy weight gain by prenatal lifestyle interventions does not prevent gestational diabetes in the LIFE-Moms consortium
- Artikel/kapitelEngelska2021
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LIBRIS-ID:oai:lup.lub.lu.se:fbd2f2f4-3e4b-4dbe-87b0-2c6f36d923e5
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https://lup.lub.lu.se/record/fbd2f2f4-3e4b-4dbe-87b0-2c6f36d923e5URI
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https://doi.org/10.1016/j.diabres.2020.108549DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Aims: To examine the effect of lifestyle (diet and physical activity) interventions on the prevalence of GDM, considering the method of GDM ascertainment and its association with early pregnancy characteristics and maternal and neonatal outcomes in the LIFE-Moms consortium. Methods: LIFE-Moms evaluated the effects of lifestyle interventions to optimize gestational weight gain in 1148 pregnant women with BMI ≥ 25 kg/m2 and without known diabetes at enrollment, compared with standard care. GDM was assessed between 24 and 31-weeks gestation by a 2-hour, 75-gram OGTT or by local clinical practice standards. Results: Lifestyle interventions initiated prior to 16 weeks reduced early excess GWG compared with standard care (0.35 ± 0.24 vs 0.43 ± 0.26 kg per week, p=<0.0001) but did not affect GDM diagnosis (11.1% vs 11.6%, p = 0.91). Using the 75-gram, 2-hour OGTT, 13. 0% of standard care and 11.0% of the intervention group had GDM by the IADPSG criteria (p = 0.45). The ‘type of diagnostic test’ did not change the result (p = 0.86). Women who developed GDM were significantly heavier, more likely to have obesity, and more likely to have dysglycemia at baseline. Conclusion: Moderate-to-high intensity lifestyle interventions grounded in behavior change theory initiated between 9 and 16-weeks gestation did not affect the prevalence of GDM despite reducing early GWG. Clinicaltrials.gov: NCT01545934, NCT01616147, NCT01771133, NCT01631747, NCT01768793, NCT01610752, NCT01812694.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Drews, Kimberly L.George Washington University
(författare)
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Klein, SamuelWashington University in St. Louis
(författare)
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Horn, Linda VanNorthwestern University
(författare)
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Wing, Rena R.Brown University
(författare)
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Pi-Sunyer, XavierColumbia University
(författare)
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Evans, MaryNational Institute of Diabetes and Digestive and Kidney Diseases
(författare)
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Joshipura, KaumudiUniversity of Puerto Rico,Harvard University
(författare)
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Arteaga, S. SoniaNational Institutes of Health, United States,National Heart Lung and Blood Institute
(författare)
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Cahill, Alison G.University of Texas at Austin
(författare)
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Clifton, Rebecca G.George Washington University
(författare)
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Couch, Kimberly A.Phoenix Indian Medical Center
(författare)
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Franks, Paul W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University(Swepub:lu)med-plf
(författare)
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Gallagher, DympnaColumbia University
(författare)
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Haire-Joshu, DebraWashington University in St. Louis
(författare)
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Martin, Corby K.Pennington Biomedical Research Center
(författare)
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Peaceman, Alan M.Northwestern University
(författare)
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Phelan, SuzanneCalifornia Polytechnic State University
(författare)
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Thom, Elizabeth A.George Washington University
(författare)
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Yanovski, Susan Z.National Institute of Diabetes and Digestive and Kidney Diseases
(författare)
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Knowler, William C.National Institute of Diabetes and Digestive and Kidney Diseases
(författare)
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Pennington Biomedical Research CenterGeorge Washington University
(creator_code:org_t)
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The LIFE-Moms Research Group
Sammanhörande titlar
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Ingår i:Diabetes Research and Clinical Practice: Elsevier BV1710168-8227
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Redman, Leanne M ...
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Drews, Kimberly ...
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Klein, Samuel
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Horn, Linda Van
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Wing, Rena R.
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Pi-Sunyer, Xavie ...
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visa fler...
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Evans, Mary
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Joshipura, Kaumu ...
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Arteaga, S. Soni ...
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Cahill, Alison G ...
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Clifton, Rebecca ...
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Couch, Kimberly ...
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Franks, Paul W.
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Gallagher, Dympn ...
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Haire-Joshu, Deb ...
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Martin, Corby K.
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Peaceman, Alan M ...
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Phelan, Suzanne
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Thom, Elizabeth ...
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Yanovski, Susan ...
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Knowler, William ...
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