Proteomic analysis of brain metastatic lung adenocarcinoma reveals intertumoral heterogeneity and specific alterations associated with the timing of brain metastases

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: onr:"swepub:oai:lup.lub.lu.se:fda422e9-4a40-4511-baea-ca7e32c9e711" > Proteomic analysis ...

1 av 1
Föregående post
Nästa post
Till träfflistan

Proteomic analysis of brain metastatic lung adenocarcinoma reveals intertumoral heterogeneity and specific alterations associated with the timing of brain metastases

Woldmar, N. (författare): Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Federal University of Rio de Janeiro

Schwendenwein, A. (författare): Medical University of Vienna

Kuras, M. (författare): Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Protein Science and Imaging,Clinical Chemistry, Malmö,Lund University Research Groups

visa fler...

Szeitz, B. (författare): Semmelweis University

Boettiger, K. (författare): Medical University of Vienna

Tisza, A. (författare): Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary

László, V. (författare): National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna

Reiniger, L. (författare): Semmelweis University,Hungarian Academy of Sciences

Bagó, A. G. (författare)

Szállási, Z. (författare): Hungarian Academy of Sciences,Danish Cancer Society,Harvard Medical School

Moldvay, J. (författare): Hungarian Academy of Sciences,National Korányi Institute for Tuberculosis and Pulmonology, Hungary

Szász, A. M. (författare): Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary

Malm, J. (författare): Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Skåne University Hospital

Horvatovich, P. (författare): University of Groningen

Pizzatti, L. (författare): Federal University of Rio de Janeiro

Domont, G. B. (författare): Federal University of Rio de Janeiro

Rényi-Vámos, F. (författare): National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Semmelweis University

Hoetzenecker, K. (författare): Medical University of Vienna

Hoda, M. A. (författare): Medical University of Vienna

Marko-Varga, G. (författare): Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH

Schelch, K. (författare): Medical University of Vienna

Megyesfalvi, Z. (författare): National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest,Semmelweis University,Medical University of Vienna

Rezeli, M. (författare): Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH

Döme, B. (författare): National Institute of Oncology, Budapest,Lund University,Skåne University Hospital,Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Semmelweis University

visa färre...

(creator_code:org_t)

Elsevier BV, 2023
2023
Engelska.
Ingår i: ESMO Open. - : Elsevier BV. - 2059-7029. ; 8:1

Relaterad länk:: http://dx.doi.org/10... (free); visa fler...; https://lup.lub.lu.s...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Background: Brain metastases are associated with considerable negative effects on patients’ outcome in lung adenocarcinoma (LADC). Here, we investigated the proteomic landscape of primary LADCs and their corresponding brain metastases. Materials and methods: Proteomic profiling was conducted on 20 surgically resected primary and brain metastatic LADC samples via label-free shotgun proteomics. After sample processing, peptides were analyzed using an Ultimate 3000 pump coupled to a QExactive HF-X mass spectrometer. Raw data were searched using PD 2.4. Further data analyses were carried out using Perseus, RStudio and GraphPad Prism. Proteomic data were correlated with clinical and histopathological parameters and the timing of brain metastases. Mass spectrometry-based proteomic data are available via ProteomeXchange with identifier PXD027259. Results: Out of the 6821 proteins identified and quantified, 1496 proteins were differentially expressed between primary LADCs and corresponding brain metastases. Pathways associated with the immune system, cell-cell/matrix interactions and migration were predominantly activated in the primary tumors, whereas pathways related to metabolism, translation or vesicle formation were overrepresented in the metastatic tumors. When comparing fast- versus slow-progressing patients, we found 454 and 298 differentially expressed proteins in the primary tumors and brain metastases, respectively. Metabolic reprogramming and ribosomal activity were prominently up-regulated in the fast-progressing patients (versus slow-progressing individuals), whereas expression of cell-cell interaction- and immune system-related pathways was reduced in these patients and in those with multiple brain metastases. Conclusions: This is the first comprehensive proteomic analysis of paired primary tumors and brain metastases of LADC patients. Our data suggest a malfunction of cellular attachment and an increase in ribosomal activity in LADC tissue, promoting brain metastasis. The current study provides insights into the biology of LADC brain metastases and, moreover, might contribute to the development of personalized follow-up strategies in LADC.

Hitta via bibliotek

ESMO Open (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: ESMO Open

Av lärosätet: Lunds universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Proteomic analysis of brain metastatic lung adenocarcinoma reveals intertumoral heterogeneity and specific alterations associated with the timing of brain metastases

Ämnesord

Nyckelord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub