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EANM practical guid...
EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations
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- Gear, Jonathan I. (författare)
- Institute of Cancer Research London,Royal Marsden NHS Foundation Trust
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- Cox, Maurice G. (författare)
- National Physical Laboratory, UK
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- Gustafsson, Johan (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Gleisner, Katarina Sjögreen (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Murray, Iain (författare)
- Royal Marsden NHS Foundation Trust,Institute of Cancer Research London
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- Glatting, Gerhard (författare)
- University of Ulm
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- Konijnenberg, Mark (författare)
- Erasmus University Medical Center
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- Flux, Glenn D. (författare)
- Royal Marsden NHS Foundation Trust,Institute of Cancer Research London
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(creator_code:org_t)
- 2018-09-14
- 2018
- Engelska.
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Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer Science and Business Media LLC. - 1619-7070 .- 1619-7089. ; 45:13, s. 2456-2474
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed dose in a site of interest as the product of the cumulated activity and a dose factor. In turn, the cumulated activity is given by the area under a time–activity curve derived from a time sequence of activity values. Each activity value is obtained in terms of a count rate, a calibration factor and a recovery coefficient (a correction for partial volume effects). The method to determine the recovery coefficient and the dose factor, both of which are dependent on the size of the volume of interest (VOI), are described. Consideration is given to propagating estimates of the quantities concerned and their associated uncertainties through the dosimetry chain to obtain an estimate of mean absorbed dose in the VOI and its associated uncertainty. This approach is demonstrated in a clinical example.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- Dosimetry
- Uncertainty analysis
Publikations- och innehållstyp
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- ref (ämneskategori)
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