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X-chromosome upregu...
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Larsson, Anton J MKarolinska Institutet
(författare)
X-chromosome upregulation is driven by increased burst frequency
- Artikel/kapitelEngelska2019
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2019-10-03
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Stockholm :Karolinska Institutet, Dept of Medical Biochemistry and Biophysics,2019
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electronicrdacarrier
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LIBRIS-ID:oai:openarchive.ki.se:10616/47264
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ISSN:1545-9993
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10616/47264hdl
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http://hdl.handle.net/10616/47264URI
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https://doi.org/10.1038/s41594-019-0306-yDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141990112URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Ohno's hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, inferred from allele-specific single-cell RNA-sequencing (scRNAseq) data from somatic mouse cells. We confirmed increased X-chromosome expression in female and male somatic cells, and remarkably found that the X-chromosome achieved upregulation by elevated burst frequencies. By monitoring differentiating female embryonic stem cells, we found that elevated burst frequency established on the active X-chromosome as X-inactivation occurred on the other allele. This provides mechanistic insights into X-chromosome upregulation.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Coucoravas, ChristosKarolinska Institutet
(författare)
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Sandberg, RickardKarolinska Institutet
(författare)
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Reinius, BjörnKarolinska Institutet
(författare)
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Karolinska Institutet
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Karolinska Institutet
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature Structural & Molecular BiologyStockholm : Karolinska Institutet, Dept of Medical Biochemistry and Biophysics1545-99931545-9985
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