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Type 1 diabetic ser...
Type 1 diabetic serum interferes with pancreatic beta-cell Ca2+-handling
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Dekki, N (författare)
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Nilsson, R (författare)
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- Norgren, S (författare)
- Karolinska Institutet
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- Rossner, SM (författare)
- Karolinska Institutet
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Appelskog, I (författare)
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- Marcus, C (författare)
- Karolinska Institutet
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Simell, O (författare)
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Pugliese, A (författare)
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Alejandro, R (författare)
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Ricordi, C (författare)
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- Berggren, PO (författare)
- Karolinska Institutet
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- Juntti-Berggren, L (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2007-11-20
- 2007
- Engelska.
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Ingår i: Bioscience reports. - : Portland Press Ltd.. - 0144-8463 .- 1573-4935. ; 27:6, s. 321-326
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this study was to clarify the frequency of patients with type 1 diabetes that have serum that increases pancreatic β-cell cytoplasmic free Ca2+ concentration, [Ca2+]i, and if such an effect is also present in serum from first-degree relatives. We also studied a possible link between the serum effect and ethnic background as well as presence of autoantibodies. Sera obtained from three different countries were investigated as follows: 82 Swedish Caucasians with newly diagnosed type 1 diabetes, 56 Americans with different duration of type 1 diabetes, 117 American first-degree relatives of type 1 diabetic patients with a mixed ethnic background and 31 Caucasian Finnish children with newly diagnosed type 1 diabetes. Changes in [Ca2+]i, upon depolarization, were measured in β-cells incubated overnight with sera from type 1 diabetic patients, first-degree relatives or healthy controls. Our data show that there is a group constituting approximately 30% of type 1 diabetic patients of different gender, age, ethnic background and duration of the disease, as well as first-degree relatives of type 1 diabetic patients, that have sera that interfere with pancreatic β-cell Ca2+-handling. This effect on β-cell [Ca2+]i could not be correlated to the presence of autoantibodies. In a defined subgroup of patients with type 1 diabetes and first-degree relatives a defect Ca2+-handling may aggravate development of β-cell destruction.
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- Av författaren/redakt...
-
Dekki, N
-
Nilsson, R
-
Norgren, S
-
Rossner, SM
-
Appelskog, I
-
Marcus, C
-
visa fler...
-
Simell, O
-
Pugliese, A
-
Alejandro, R
-
Ricordi, C
-
Berggren, PO
-
Juntti-Berggren, ...
-
visa färre...
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Karolinska Institutet