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The importance of H...
The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation
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Shaw, BE (författare)
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Gooley, TA (författare)
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Malkki, M (författare)
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Madrigal, JA (författare)
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Begovich, AB (författare)
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Horowitz, MM (författare)
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Gratwohl, A (författare)
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- Ringden, O (författare)
- Karolinska Institutet
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Marsh, SGE (författare)
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Petersdorf, EW (författare)
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(creator_code:org_t)
- American Society of Hematology, 2007
- 2007
- Engelska.
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 110:13, s. 4560-4566
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Hematopoietic cell transplantation (HCT) from an HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele–matched unrelated donor is a well-recognized life-saving treatment modality for patients with hematologic disorders. The morbidity and mortality from clinically significant acute graft-versus-host disease (aGVHD) remains a limitation. The extent to which transplantation outcome may be improved with donor matching for HLA-DP is not well defined. The risks of aGVHD, relapse, and mortality associated with HLA-DPB1 allele mismatching were determined in 5929 patients who received a myeloablative HCT from an HLA-A–, HLA-B–, HLA-C–, HLA-DRB1–, and HLA-DQB1–matched or –mismatched donor. There was a statistically significantly higher risk of both grades 2 to 4 aGVHD (odds ratio [OR] = 1.33; P < .001) and grades 3 to 4 aGVHD (OR = 1.26; P < .001) after HCT from an HLA-DPB1–mismatched donor compared with a matched donor. The increased risk of aGVHD was accompanied by a statistically significantly decrease in disease relapse (hazard ratio [HR] = 0.82; P = .01). HLA-DPB1 functions as a classical transplantation antigen. The increased risk of GVHD associated with HLA-DPB1 mismatching is accompanied by a lower risk of relapse. Knowledge of the DPB1 matching status prior to transplantation will aid in more precise risk stratification for the individual patient.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Blood
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Till lärosätets databas
- Av författaren/redakt...
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Shaw, BE
-
Gooley, TA
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Malkki, M
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Madrigal, JA
-
Begovich, AB
-
Horowitz, MM
-
visa fler...
-
Gratwohl, A
-
Ringden, O
-
Marsh, SGE
-
Petersdorf, EW
-
visa färre...
- Artiklar i publikationen
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Blood
- Av lärosätet
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Karolinska Institutet