onr:"swepub:oai:prod.swepub.kib.ki.se:116825675"
Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:116825675" > Nuclear envelope de...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02536naa a2200385 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:116825675 | |
| 003 | SwePub | |
| 008 | 240701s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1168256752 URI |
| 024 | 7 | a https://doi.org/10.1083/jcb.2008010962 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Espada, J4 aut |
| 245 | 1 0 | a Nuclear envelope defects cause stem cell dysfunction in premature-aging mice |
| 264 | c 2008-03-31 | |
| 264 | 1 | b Rockefeller University Press,c 2008 |
| 520 | a Nuclear lamina alterations occur in physiological aging and in premature aging syndromes. Because aging is also associated with abnormal stem cell homeostasis, we hypothesize that nuclear envelope alterations could have an important impact on stem cell compartments. To evaluate this hypothesis, we examined the number and functional competence of stem cells in Zmpste24-null progeroid mice, which exhibit nuclear lamina defects. We show that Zmpste24 deficiency causes an alteration in the number and proliferative capacity of epidermal stem cells. These changes are associated with an aberrant nuclear architecture of bulge cells and an increase in apoptosis of their supporting cells in the hair bulb region. These alterations are rescued in Zmpste24−/−Lmna+/− mutant mice, which do not manifest progeroid symptoms. We also report that molecular signaling pathways implicated in the regulation of stem cell behavior, such as Wnt and microphthalmia transcription factor, are altered in Zmpste24−/− mice. These findings establish a link between age-related nuclear envelope defects and stem cell dysfunction. | |
| 700 | 1 | a Varela, I4 aut |
| 700 | 1 | a Flores, I4 aut |
| 700 | 1 | a Ugalde, AP4 aut |
| 700 | 1 | a Cadinanos, J4 aut |
| 700 | 1 | a Pendas, AM4 aut |
| 700 | 1 | a Stewart, CL4 aut |
| 700 | 1 | a Tryggvason, Ku Karolinska Institutet4 aut |
| 700 | 1 | a Blasco, MA4 aut |
| 700 | 1 | a Freije, JMP4 aut |
| 700 | 1 | a Lopez-Otin, C4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t The Journal of cell biologyd : Rockefeller University Pressg 181:1, s. 27-35q 181:1<27-35x 1540-8140x 0021-9525 |
| 856 | 4 | u https://rupress.org/jcb/article-pdf/181/1/27/1337146/jcb_200801096.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:116825675 |
| 856 | 4 8 | u https://doi.org/10.1083/jcb.200801096 |
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