Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:116899678" >
EBV-encoded EBNA-6 ...
EBV-encoded EBNA-6 binds and targets MRS18-2 to the nucleus, resulting in the disruption of pRb-E2F1 complexes
-
- Kashuba, E (författare)
- Karolinska Institutet
-
Yurchenko, M (författare)
-
Yenamandra, SP (författare)
-
visa fler...
-
Snopok, B (författare)
-
- Isaguliants, M (författare)
- Karolinska Institutet
-
- Szekely, L (författare)
- Karolinska Institutet
-
- Klein, G (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2008-04-08
- 2008
- Engelska.
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 105:14, s. 5489-5494
- Relaterad länk:
-
http://www.pnas.org/...
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Epstein–Barr virus (EBV), like other DNA tumor viruses, induces an S-phase in the natural host cell, the human B lymphocyte. This is linked with blast transformation. It is believed that the EBV-encoded nuclear antigen 6 (EBNA-6) is involved in the regulation of cell cycle entry. However, the possible mechanism of this regulation is not approached. In our current study, we found that EBNA-6 binds to a MRPS18-2 protein, and targets it to the nucleus. We found that MRPS18-2 binds to both hypo- and hyperphosphorylated forms of Rb protein specifically. This binding targets the small pocket of pRb, which is a site of interaction with E2F1. The MRPS18-2 competes with the binding of E2F1 to pRb, thereby raising the level of free E2F1. Our experimental data suggest that EBNA-6 may play a major role in the entry of EBV infected B cells into the S phase by binding to and raising the level of nuclear MRPS18-2, protein. This would inhibit pRb binding to E2F1 competitively and lift the block preventing S-phase entry.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas