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Measurement of stri...
Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [11C]PE2I: quantitative modeling and test-retest reproducibility
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Hirvonen, J (författare)
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Johansson, J (författare)
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Teras, M (författare)
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Oikonen, V (författare)
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Lumme, V (författare)
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Virsu, P (författare)
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Roivainen, A (författare)
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Nagren, K (författare)
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- Halldin, C (författare)
- Karolinska Institutet
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- Farde, L (författare)
- Karolinska Institutet
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Hietala, J (författare)
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(creator_code:org_t)
- 2008-01-09
- 2008
- Engelska.
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Ingår i: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. - : SAGE Publications. - 0271-678X. ; 28:5, s. 1059-1069
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https://journals.sag...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- [11C]PE2I is a novel positron emission tomography (PET) radiotracer for the dopamine transporter (DAT). The reproducibility and reliability of [11C]PE2I measurements, especially in the small DAT-rich brain regions, is unknown and of critical importance to the interpretation of the data. Five healthy volunteers were scanned twice during the same day using [11C]PE2I and the HRRT PET scanner. Methods based on metabolite-corrected arterial plasma curve and reference region were used to estimate distribution volumes ( VT) and binding potential ( BP). Within-subject and between-subject variabilities were compared. [11C]PE2I accumulated in the DAT-rich striatum and the midbrain. Equilibrium of specific binding appeared late in the striatum, whereas it was reached earlier in the midbrain. Plasma metabolite analysis showed that the potentially brain-penetrant 4-hydroxymethyl metabolite represented 15% to 20% of total plasma radioactivity. VT and BP measurements were associated with low within-subject variability. Measurement of DAT binding in small brain regions, including the substantia nigra, is reproducible and reliable using [11C]PE2I and high-resolution research tomograph. A scanning time of more than 70 mins is required for the striatum, while less is sufficient for DAT quantification in the midbrain. The previously suggested involvement of the potentially brain-penetrant radioactive metabolite in the quantification should be further studied.
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- art (ämneskategori)
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- Av författaren/redakt...
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Hirvonen, J
-
Johansson, J
-
Teras, M
-
Oikonen, V
-
Lumme, V
-
Virsu, P
-
visa fler...
-
Roivainen, A
-
Nagren, K
-
Halldin, C
-
Farde, L
-
Hietala, J
-
visa färre...
- Artiklar i publikationen
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Journal of cereb ...
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Journal of Cereb ...
- Av lärosätet
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Karolinska Institutet