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Safety analysis of ...
Safety analysis of ex vivo-expanded NK and NK-like T cells administered to cancer patients: a phase I clinical study
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Barkholt, L (författare)
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- Alici, E (författare)
- Karolinska Institutet
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- Conrad, R (författare)
- Karolinska Institutet
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- Sutlu, T (författare)
- Karolinska Institutet
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Gilljam, M (författare)
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Stellan, B (författare)
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- Christensson, B (författare)
- Karolinska Institutet
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- Guven, H (författare)
- Karolinska Institutet
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- Bjorkstrom, NK (författare)
- Karolinska Institutet
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- Soderdahl, G (författare)
- Karolinska Institutet
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- Cederlund, K (författare)
- Karolinska Institutet
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- Kimby, E (författare)
- Karolinska Institutet
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Aschan, J (författare)
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- Ringden, O (författare)
- Karolinska Institutet
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- Ljunggren, HG (författare)
- Karolinska Institutet
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Dilber, MS (författare)
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(creator_code:org_t)
- Future Medicine Ltd, 2009
- 2009
- Engelska.
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Ingår i: Immunotherapy. - : Future Medicine Ltd. - 1750-7448 .- 1750-743X. ; 1:5, s. 753-764
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.2...
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Abstract
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- The chimeric state after allogeneic hematopoietic stem cell transplantation provides a platform for adoptive immunotherapy using donor-derived immune cells. The major risk with donor lymphocyte infusions (DLIs) is the development of graft-versus-host disease (GvHD). Development of new DLI products with antitumor reactivity and reduced GvHD risk represents a challenging task in cancer immunotherapy. Although natural killer (NK) and NK-like T cells are promising owing to their antitumor activity, their low concentrations in peripheral blood mononuclear cells reduces their utility in DLIs. We have recently developed a system that allows expansion of clinical-grade NK and NK-like T cells in large numbers. In this study, the safety of donor-derived long-term ex vivo-expanded human NK and NK-like T cells given as DLIs was investigated as immunotherapy for cancer in five patients following allogeneic stem cell infusion. Infusion of the cells was safe whether administered alone or with IL-2 subcutaneously. No signs of acute GvHD were observed. One patient with hepatocellular carcinoma showed markedly decreased serum α-fetoprotein levels following cell infusions. These findings suggest that the use of ex vivo-expanded NK and NK-like T cells is safe and appears an attractive approach for further clinical evaluation in cancer patients.
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Barkholt, L
-
Alici, E
-
Conrad, R
-
Sutlu, T
-
Gilljam, M
-
Stellan, B
-
visa fler...
-
Christensson, B
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Guven, H
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Bjorkstrom, NK
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Soderdahl, G
-
Cederlund, K
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Kimby, E
-
Aschan, J
-
Ringden, O
-
Ljunggren, HG
-
Dilber, MS
-
visa färre...
- Artiklar i publikationen
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Immunotherapy
- Av lärosätet
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Karolinska Institutet