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Pancreatic cancer c...
Pancreatic cancer cells expressing hypoxia-inducible factor-1α tend to be adjacent to intratumoral blood vessels
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Cheng, BQ (författare)
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- Segersvard, R (författare)
- Karolinska Institutet
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- Permert, J (författare)
- Karolinska Institutet
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Wang, F (författare)
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(creator_code:org_t)
- 2010-10-01
- 2010
- Engelska.
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Ingår i: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. - : S. Karger AG. - 1421-9921. ; 45:3-4, s. 134-137
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- We investigated whether cells expressing hypoxia-inducible factor-1α (HIF-1α) are specially related to blood vessels in human pancreatic tumors. HIF-1α and blood vessels were stained in 7 pancreatic ductal adenocarcinomas (PDAC) and 3 nonmalignant tumors. HIF-1α<sup>+</sup> cells accounted for 37 ± 5% of the total PDAC cells and increased to 52 ± 4% in perivascular PDAC cells and to 67 ± 4% in PDAC cells found in intratumoral blood vessels. In nonmalignant tumors, 12 ± 3% of the total tumoral cells examined were HIF-1α<sup>+</sup>, and HIF-1α<sup>+</sup> cells decreased to 2 ± 0.3% in perivascular cells examined in the tumors. In conclusion, HIF-1α<sup>+</sup> cells in PDAC and nonmalignant pancreatic tumors differ not only in their amounts but also in their relation to intratumoral blood vessels. HIF-1α<sup>+</sup> cells usually are adjacent to intratumoral blood vessels in PDAC tumors, but are farther away from the vessels in nonmalignant pancreatic tumors.
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