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Manganese dioxide m...
Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine
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Baiget, J (författare)
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- Llona-Minguez, S (författare)
- Karolinska Institutet
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Lang, S (författare)
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MacKay, SP (författare)
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Suckling, CJ (författare)
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Sutcliffe, OB (författare)
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(creator_code:org_t)
- 2011-10-12
- 2011
- Engelska.
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Ingår i: Beilstein journal of organic chemistry. - : Beilstein Institut. - 1860-5397. ; 7, s. 1407-1411
- Relaterad länk:
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https://www.beilstei...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- The carboline ring system is an important pharmacophore found in a number of biologically important targets. Development of synthetic routes for the preparation of these compounds is important in order to prepare a range of analogues containing the carboline heterocyclic moiety. A manganese dioxide mediated one-pot method starting with an activated alcohol and consisting of alcohol oxidation, Pictet–Spengler cyclisation, and oxidative aromatisation, offers a convenient process that allows access to β-carbolines. This one-pot process for the preparation of methyl 9H-pyrido[3,4-b]indole-1-carboxylate has subsequently been used as the key step in the synthesis of alangiobussinine and a closely related analogue.
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