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Regional difference...
Regional differences in effects of APOE ε4 on cognitive impairment in non-demented subjects
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Norberg, J (författare)
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- Graff, C (författare)
- Karolinska Institutet
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- Almkvist, O (författare)
- Karolinska Institutet
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Ewers, M (författare)
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Frisoni, GB (författare)
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Frolich, L (författare)
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Hampel, H (författare)
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Jones, RW (författare)
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Kehoe, PG (författare)
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Lenoir, H (författare)
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Minthon, L (författare)
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Nobili, F (författare)
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Rikkert, MO (författare)
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Rigaud, AS (författare)
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Scheltens, P (författare)
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Soininen, H (författare)
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Spiru, L (författare)
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Tsolaki, M (författare)
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- Wahlund, LO (författare)
- Karolinska Institutet
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Vellas, B (författare)
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Wilcock, G (författare)
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Elias-Sonnenschein, LS (författare)
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Verhey, FRJ (författare)
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Visser, PJ (författare)
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(creator_code:org_t)
- 2011-09-22
- 2011
- Engelska.
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Ingår i: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 32:2, s. 135-142
- Relaterad länk:
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https://epub.ub.uni-...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- <i>Background:</i> The <i>APOE</i> ε4 allele is a risk factor for Alzheimer’s disease (AD). <i>APOE</i> ε4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the <i>APOE</i> ε4 allele and cognitive impairment varied across Northern, Middle and Southern Europe. We also investigated whether a north-south gradient existed in subjects with subjective cognitive impairment (SCI), amnestic mild cognitive impairment (MCI) and non-amnestic MCI. <i>Methods:</i> Data from 16 centers across Europe were analyzed. <i>Results:</i> A north-south gradient in <i>APOE</i> ε4 prevalence existed in the total sample (62.7% for <i>APOE</i> ε4 carriers in the northern region, 42.1% in the middle region, and 31.5% in the southern region) and in subjects with SCI and amnestic MCI separately. Only in Middle Europe was the <i>APOE</i> ε4 allele significantly associated with poor performance on tests of delayed recall and learning, as well as with the amnestic subtype of MCI. <i>Conclusion:</i> The <i>APOE</i> ε4 allele frequencies in subjects with SCI and amnestic MCI have a north-south gradient. The relation between the <i>APOE</i> ε4 allele and cognition is region dependent.
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- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Norberg, J
-
Graff, C
-
Almkvist, O
-
Ewers, M
-
Frisoni, GB
-
Frolich, L
-
visa fler...
-
Hampel, H
-
Jones, RW
-
Kehoe, PG
-
Lenoir, H
-
Minthon, L
-
Nobili, F
-
Rikkert, MO
-
Rigaud, AS
-
Scheltens, P
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Soininen, H
-
Spiru, L
-
Tsolaki, M
-
Wahlund, LO
-
Vellas, B
-
Wilcock, G
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Elias-Sonnensche ...
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Verhey, FRJ
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Visser, PJ
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visa färre...
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Dementia and ger ...
- Av lärosätet
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Karolinska Institutet