onr:"swepub:oai:prod.swepub.kib.ki.se:124979532"
Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:124979532" > Impact of common va...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03841naa a2200733 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:124979532 | |
| 003 | SwePub | |
| 008 | 240701s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1249795322 URI |
| 024 | 7 | a https://doi.org/10.2337/db11-15152 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Billings, LK4 aut |
| 245 | 1 0 | a Impact of common variation in bone-related genes on type 2 diabetes and related traits |
| 264 | c 2012-07-17 | |
| 264 | 1 | b American Diabetes Association,c 2012 |
| 520 | a Exploring genetic pleiotropy can provide clues to a mechanism underlying the observed epidemiological association between type 2 diabetes and heightened fracture risk. We examined genetic variants associated with bone mineral density (BMD) for association with type 2 diabetes and glycemic traits in large well-phenotyped and -genotyped consortia. We undertook follow-up analysis in ∼19,000 individuals and assessed gene expression. We queried single nucleotide polymorphisms (SNPs) associated with BMD at levels of genome-wide significance, variants in linkage disequilibrium (r2 > 0.5), and BMD candidate genes. SNP rs6867040, at the ITGA1 locus, was associated with a 0.0166 mmol/L (0.004) increase in fasting glucose per C allele in the combined analysis. Genetic variants in the ITGA1 locus were associated with its expression in the liver but not in adipose tissue. ITGA1 variants appeared among the top loci associated with type 2 diabetes, fasting insulin, β-cell function by homeostasis model assessment, and 2-h post–oral glucose tolerance test glucose and insulin levels. ITGA1 has demonstrated genetic pleiotropy in prior studies, and its suggested role in liver fibrosis, insulin secretion, and bone healing lends credence to its contribution to both osteoporosis and type 2 diabetes. These findings further underscore the link between skeletal and glucose metabolism and highlight a locus to direct future investigations. | |
| 700 | 1 | a Hsu, YH4 aut |
| 700 | 1 | a Ackerman, RJ4 aut |
| 700 | 1 | a Dupuis, J4 aut |
| 700 | 1 | a Voight, BF4 aut |
| 700 | 1 | a Rasmussen-Torvik, LJ4 aut |
| 700 | 1 | a Hercberg, S4 aut |
| 700 | 1 | a Lathrop, M4 aut |
| 700 | 1 | a Barnes, D4 aut |
| 700 | 1 | a Langenberg, C4 aut |
| 700 | 1 | a Hui, JN4 aut |
| 700 | 1 | a Fu, M4 aut |
| 700 | 1 | a Bouatia-Naji, N4 aut |
| 700 | 1 | a Lecoeur, C4 aut |
| 700 | 1 | a An, P4 aut |
| 700 | 1 | a Magnusson, PKu Karolinska Institutet4 aut |
| 700 | 1 | a Surakka, I4 aut |
| 700 | 1 | a Ripatti, S4 aut |
| 700 | 1 | a Christiansen, L4 aut |
| 700 | 1 | a Dalgard, C4 aut |
| 700 | 1 | a Folkersen, L4 aut |
| 700 | 1 | a Grundberg, E4 aut |
| 700 | 1 | a Eriksson, Pu Karolinska Institutet4 aut |
| 700 | 1 | a Kaprio, J4 aut |
| 700 | 1 | a Kyvik, KO4 aut |
| 700 | 1 | a Pedersen, NLu Karolinska Institutet4 aut |
| 700 | 1 | a Borecki, IB4 aut |
| 700 | 1 | a Province, MA4 aut |
| 700 | 1 | a Balkau, B4 aut |
| 700 | 1 | a Froguel, P4 aut |
| 700 | 1 | a Shuldiner, AR4 aut |
| 700 | 1 | a Palmer, LJ4 aut |
| 700 | 1 | a Wareham, N4 aut |
| 700 | 1 | a Meneton, P4 aut |
| 700 | 1 | a Johnson, T4 aut |
| 700 | 1 | a Pankow, JS4 aut |
| 700 | 1 | a Karasik, D4 aut |
| 700 | 1 | a Meigs, JB4 aut |
| 700 | 1 | a Kiel, DP4 aut |
| 700 | 1 | a Florez, JC4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Diabetesd : American Diabetes Associationg 61:8, s. 2176-2186q 61:8<2176-2186x 1939-327Xx 0012-1797 |
| 856 | 4 | u https://diabetes.diabetesjournals.org/content/diabetes/61/8/2176.full.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:124979532 |
| 856 | 4 8 | u https://doi.org/10.2337/db11-1515 |
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- Billings, LK
- Hsu, YH
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- Hercberg, S
- Lathrop, M
- Barnes, D
- Langenberg, C
- Hui, JN
- Fu, M
- Bouatia-Naji, N
- Lecoeur, C
- An, P
- Magnusson, PK
- Surakka, I
- Ripatti, S
- Christiansen, L
- Dalgard, C
- Folkersen, L
- Grundberg, E
- Eriksson, P
- Kaprio, J
- Kyvik, KO
- Pedersen, NL
- Borecki, IB
- Province, MA
- Balkau, B
- Froguel, P
- Shuldiner, AR
- Palmer, LJ
- Wareham, N
- Meneton, P
- Johnson, T
- Pankow, JS
- Karasik, D
- Meigs, JB
- Kiel, DP
- Florez, JC
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