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Variants within STA...
Variants within STAT genes reveal association with anticitrullinated protein antibody-negative rheumatoid arthritis in 2 European populations
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- Seddighzadeh, M (författare)
- Karolinska Institutet
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Gonzalez, A (författare)
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Ding, B (författare)
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Ferreiro-Iglesias, A (författare)
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Gomez-Reino, JJ (författare)
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- Klareskog, L (författare)
- Karolinska Institutet
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- Alfredsson, L (författare)
- Karolinska Institutet
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Dunussi-Joannopoulos, K (författare)
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Clark, JD (författare)
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- Padyukov, L (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2012-07-01
- 2012
- Engelska.
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Ingår i: The Journal of rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 39:8, s. 1509-1516
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- STAT3 and 4 are, among other factors, critical for the interleukin 12 (IL-12)-mediated Th1 response, for transfer of IL-23 signals, and for survival and expansion of Th17 cells. We investigated the association of STAT3 and STAT4 polymorphisms with serologically distinct subgroups of rheumatoid arthritis (RA).Methods.A total of 41 single-nucleotide polymorphisms (SNP) within STAT3 and STAT1-STAT4 loci were investigated in a Swedish cohort of 2043 RA cases and 1115 controls. Nine of the associated SNP were tested in a Spanish cohort of 1223 RA cases and 1090 controls.Results.Fourteen SNP in the STAT3 and STAT1-STAT4 loci were associated with anticitrullinated protein antibody (ACPA)-negative RA in the Swedish cohort. Three of the SNP inSTAT4and 2 SNP inSTAT3remained associated with ACPA-negative RA after considering the Spanish results. In addition, rs7574865 and rs10181656, inSTAT4, were associated with ACPA-positive RA in the Swedish study. One of these SNP, rs7574865, showed a similar pattern of the association in serologically distinct subgroups of RA in a metaanalysis of all 7 published studies.Conclusion.Our findings suggest that variants in STAT genes may contribute differentially to susceptibility to RA in seropositive and in seronegative patients.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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