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Increased CD8+ cent...
Increased CD8+ central memory T cells in patients with multiple sclerosis
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2017-01-30
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SAGE Publications,2007
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:12553078
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http://kipublications.ki.se/Default.aspx?queryparsed=id:12553078URI
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https://doi.org/10.1177/1352458506069246DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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AT-cell-mediated autoimmune process against central nervous system myelin is believed to underlie the pathogenesis of multiple sclerosis (MS). Formation of immunological memory is based on the differentiation of naïve T cells to memory T cells after exposure to antigens and specific cytokines. The aim of this study was to analyse peripheral blood mononuclear cells in patients with MS for different T-cell subsets including naïve and memory T cells. Flow cytometry and enzyme-linked immunosorbent assay were used to analyse memory T-cell subsets and plasma concentration of interleukin-15 (IL-15) in peripheral blood of MS patients, patients with other neurological disorders and healthy controls. MS patients had a skewed distribution of T cells with an increased level of CD8 + /CCR7 + /CD45RA— central memory T cells (TCM) compared to healthy controls. In addition, MS patients showed significantly higher levels of plasma IL-15 than healthy controls did. Upregulated CD8+ TCM in MS patients may reflect a persistent chronic inflammatory response that may have been induced during early stages of the disease. This derangement may be important for maintaining chronic inflammation in MS. Multiple Sclerosis 2007; 13: 149–155. http://msj.sagepub.com
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Fang, LB
(författare)
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Hjelmstrom, PKarolinska Institutet
(författare)
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Gao, XG
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Multiple sclerosis (Houndmills, Basingstoke, England): SAGE Publications13:2, s. 149-1551352-45851477-0970
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