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TLR7 contributes to...
TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection
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Stegemann-Koniszewski, S (författare)
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Gereke, M (författare)
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Orrskog, S (författare)
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Lienenklaus, S (författare)
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Pasche, B (författare)
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Bader, SR (författare)
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Gruber, AD (författare)
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Akira, S (författare)
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Weiss, S (författare)
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- Henriques-Normark, B (författare)
- Karolinska Institutet
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Bruder, D (författare)
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Gunzer, M (författare)
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(creator_code:org_t)
- 2012-11-15
- 2013
- Engelska.
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Ingår i: Journal of innate immunity. - : S. Karger AG. - 1662-8128 .- 1662-811X. ; 5:1, s. 84-96
- Relaterad länk:
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https://www.karger.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Increased risk for bacterial superinfections substantially contributes to the mortality caused by influenza A virus (IAV) epidemics. While the mechanistic basis for this lethal synergism is still insufficiently understood, immune modulation through the viral infection has been shown to be involved. Since the pattern-recognition receptor (PRR) toll-like receptor 7 (TLR7) is a major sensor for the viral genome, we studied how IAV recognition by TLR7 influences the development of secondary pneumococcal infection. In a mouse model of IAV, TLR7-deficient hosts induced a potent antiviral response and showed unchanged survival. In secondary pneumococcal infection during acute influenza, TLR7ko mice showed a fatal outcome similar to wild-type (WT) hosts, despite significantly delayed disease progression. Also, when bacterial superinfection occurred after virus clearance, WT and TLR7-deficient hosts showed similar mortality, even though we found the phagocytic activity of alveolar macrophages isolated from IAV-pre-infected hosts to be enhanced in TLR7ko over WT mice. Thus, we show that a virus-sensing PRR modulates the progression of secondary pneumococcal infection following IAV. However, the fatal overall outcome in WT as well as TLR7ko hosts suggests that processes distinct from TLR7-triggering override the contribution of this single PRR.
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Stegemann-Konisz ...
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Gereke, M
-
Orrskog, S
-
Lienenklaus, S
-
Pasche, B
-
Bader, SR
-
visa fler...
-
Gruber, AD
-
Akira, S
-
Weiss, S
-
Henriques-Normar ...
-
Bruder, D
-
Gunzer, M
-
visa färre...
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Journal of innat ...
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Karolinska Institutet