HIF isoforms in the skin differentially regulate systemic arterial pressure

• The differential expression of the hypoxia-inducible factor-alpha (HIF-α) isoforms in the skin of mice influences vascular resistance and is correlated with homeostatic regulation of nitric oxide synthesis. A correlation between HIF isoform expression and hypertension was found in skin biopsies from human subjects, and may indicate a mechanism in the etiology of idiopathic hypertension.

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