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Dialysis adequacy i...
Dialysis adequacy indices and body composition in male and female patients on peritoneal dialysis
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Debowska, M (författare)
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Paniagua, R (författare)
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Ventura, MDJ (författare)
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Avila-Diaz, M (författare)
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Prado-Uribe, C (författare)
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Mora, C (författare)
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Garcia-Lopez, E (författare)
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- Qureshi, AR (författare)
- Karolinska Institutet
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- Lindholm, B (författare)
- Karolinska Institutet
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Waniewski, J (författare)
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(creator_code:org_t)
- 2014-07-01
- 2014
- Engelska.
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Ingår i: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. - : SAGE Publications. - 1718-4304 .- 0896-8608. ; 34:4, s. 417-425
- Relaterad länk:
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https://europepmc.or...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Creatinine clearance scaled to body surface area (BSA) and urea KT/V normalized to total body water (TBW) are used as indices for peritoneal dialysis (PD) adequacy. We investigated relationships of indices of dialysis adequacy (including KT/V, KT, clearance, dialysate over plasma concentration ratio) and anthropometric and body composition parameters (BSA, TBW, body mass index (BMI), weight, height, fat mass (FM), and fat-free mass (FFM)) in male and female patients on continuous ambulatory peritoneal dialysis. Methods Ninety-nine stable patients (56 males) performed four 24-hr collections of drained dialysate for four dialysis schedules with three daily exchanges of glucose 1.36% and one night exchange of either: 1) glucose 1.36%, 2) glucose 2.27%, 3) glucose 3.86% or 4) icodextrin 7.5%. Results KT and dialysate over plasma concentration ratio, CD/CP, for urea and creatinine were similar for males and females and, in general, did not depend on body-size parameters including V (= TBW), which means that the overall capacity of the transport system in females and males is similar. However, after normalization of KT to V or 1.73/BSA yielding KT/V and creatinine clearance, Cl(1.73/BSA), respectively, the normalized indices were substantially higher in females than in males and correlated inversely with body-size parameters, especially in males. Conclusions As KT/V depends strongly on body size, treatment target values for KT/V should take body size and therefore also gender into account. As KT is less influenced by body size, body composition and gender, KT should be considered as a potential auxiliary index in PD.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Debowska, M
-
Paniagua, R
-
Ventura, MDJ
-
Avila-Diaz, M
-
Prado-Uribe, C
-
Mora, C
-
visa fler...
-
Garcia-Lopez, E
-
Qureshi, AR
-
Lindholm, B
-
Waniewski, J
-
visa färre...
- Artiklar i publikationen
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Peritoneal dialy ...
- Av lärosätet
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Karolinska Institutet