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Defects in β-cell C...
Defects in β-cell Ca2+ dynamics in age-induced diabetes
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- Li, LS (författare)
- Karolinska Institutet
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Trifunovic, A (författare)
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- Kohler, M (författare)
- Karolinska Institutet
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- Wang, YX (författare)
- Karolinska Institutet
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Berglund, JP (författare)
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- Illies, C (författare)
- Karolinska Institutet
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- Juntti-Berggren, L (författare)
- Karolinska Institutet
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- Larsson, NG (författare)
- Karolinska Institutet
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- Berggren, PO (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2014-11-13
- 2014
- Engelska.
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Ingår i: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 63:12, s. 4100-4114
- Relaterad länk:
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https://diabetes.dia...
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http://kipublication...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Little is known about the molecular mechanisms underlying age-dependent deterioration in β-cell function. We now demonstrate that age-dependent impairment in insulin release, and thereby glucose homeostasis, is associated with subtle changes in Ca2+ dynamics in mouse β-cells. We show that these changes are likely to be accounted for by impaired mitochondrial function and to involve phospholipase C/inositol 1,4,5-trisphosphate–mediated Ca2+ mobilization from intracellular stores as well as decreased β-cell Ca2+ influx over the plasma membrane. We use three mouse models, namely, a premature aging phenotype, a mature aging phenotype, and an aging-resistant phenotype. Premature aging is studied in a genetically modified mouse model with an age-dependent accumulation of mitochondrial DNA mutations. Mature aging is studied in the C57BL/6 mouse, whereas the 129 mouse represents a model that is more resistant to age-induced deterioration. Our data suggest that aging is associated with a progressive decline in β-cell mitochondrial function that negatively impacts on the fine tuning of Ca2+ dynamics. This is conceptually important since it emphasizes that even relatively modest changes in β-cell signal transduction over time lead to compromised insulin release and a diabetic phenotype.
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- art (ämneskategori)
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