onr:"swepub:oai:prod.swepub.kib.ki.se:130165034"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02728naa a2200349 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:130165034 | |
| 003 | SwePub | |
| 008 | 240913s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1301650342 URI |
| 024 | 7 | a https://doi.org/10.1177/13524585145327002 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lundstrom, W4 aut |
| 245 | 1 0 | a Interferon beta treatment of multiple sclerosis increases serum interleukin-7 |
| 264 | c 2014-05-12 | |
| 264 | 1 | b SAGE Publications,c 2014 |
| 520 | a Interleukin-7 (IL-7) is a non-redundant cytokine for T-cell development and survival. The IL-7 signaling pathway has been genetically and functionally associated with several autoimmune diseases including multiple sclerosis (MS). Objective: The objective of this paper is to elucidate the effect of the widely used immunomodulatory MS therapy interferon beta (IFNβ) on IL-7 homeostasis. Methods: Swedish MS patients were screened for IL-7 concentration in serum and blood cell counts. IL-7 receptor alpha chain (IL-7Rα) expression was determined by semi-quantitative real-time polymerase chain reaction (PCR) and flow cytometry. Results: IFNβ treatment led to significantly increased serum IL-7 levels (mean: 17 pg/ml) compared with healthy controls (mean: 7.6 pg/ml) and natalizumab-treated patients (mean: 5.3 pg/ml). In vitro and in vivo, peripheral blood leukocytes showed decreased IL-7Rα expression and IL-7 consumption upon IFNβ exposure, suggesting that their IL-7 responsiveness is impaired during treatment. Conclusions: MS patients undergoing IFNβ treatment have increased serum IL-7 levels and decreased IL-7 consumption. Given IL-7’s important role in T-cell immunity, this relationship may be highly relevant for IFNβ’s treatment efficacy. | |
| 700 | 1 | a Hermanrud, Cu Karolinska Institutet4 aut |
| 700 | 1 | a Sjostrand, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Brauner, Su Karolinska Institutet4 aut |
| 700 | 1 | a Wahren-Herlenius, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Olsson, Tu Karolinska Institutet4 aut |
| 700 | 1 | a Karrenbauer, Vu Karolinska Institutet4 aut |
| 700 | 1 | a Hillert, Ju Karolinska Institutet4 aut |
| 700 | 1 | a Fogdell-Hahn, Au Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Multiple sclerosis (Houndmills, Basingstoke, England)d : SAGE Publicationsg 20:13, s. 1727-1736q 20:13<1727-1736x 1477-0970x 1352-4585 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130165034 |
| 856 | 4 8 | u https://doi.org/10.1177/1352458514532700 |
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