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Young capillary ves...
Young capillary vessels rejuvenate aged pancreatic islets
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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2014-11-17
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Proceedings of the National Academy of Sciences,2014
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:130257644
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130257644URI
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https://doi.org/10.1073/pnas.1414053111DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The regulation of blood glucose is a homeostatic process that declines with age, but it is unknown whether this disturbance is a consequence of intrinsic dysfunction of the regulatory organ, the pancreatic islet. In marked contrast to the widely held notion that the insulin-producing pancreatic beta cell loses function with wear and tear, and thus causes age-related disturbances in glucose homeostasis, we show that mouse and human beta cells are fully functional at advanced age. The pancreatic islet as an organ, however, is threatened by vascular senescence. Replacing the islet vasculature in aged islet grafts rejuvenates the islet and fully restores glucose homeostasis, indicating that islet blood vessels should be targeted to mitigate frail glucose homeostasis associated with aging.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Molina, J
(författare)
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Drigo, RAE
(författare)
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Abdulreda, MH
(författare)
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Jeon, WB
(författare)
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Berggren, POKarolinska Institutet
(författare)
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Caicedo, A
(författare)
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Nam, HG
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences111:49, s. 17612-176171091-6490
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Ingår i:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences111:49, s. 17612-176170027-8424
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