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Multiple sclerosis ...
Multiple sclerosis in older adults: the clinical profile and impact of interferon Beta treatment
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Shirani, A (författare)
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Zhao, YS (författare)
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Petkau, J (författare)
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Gustafson, P (författare)
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Karim, ME (författare)
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Evans, C (författare)
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Kingwell, E (författare)
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van der Kop, ML (författare)
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Oger, J (författare)
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Tremlett, H (författare)
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- Hindawi Limited, 2015
- 2015
- Engelska.
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Ingår i: BioMed research international. - : Hindawi Limited. - 2314-6141 .- 2314-6133. ; 2015, s. 451912-
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Background. We examined (1) patient characteristics and disease-modifying drug (DMD) exposure in late-onset (LOMS, ≥50 years at symptom onset) versus adult-onset (AOMS, 18–<50 years) MS and (2) the association between interferon-beta (IFNβ) and disability progression in older relapsing-onset MS adults (≥50 years).Methods. This retrospective study (1980–2004, British Columbia, Canada) included 358 LOMS and 5627 AOMS patients. IFNβ-treated relapsing-onset MS patients aged ≥50 (regardless of onset age, 90) were compared with 171 contemporary and 106 historical controls. Times to EDSS 6 from onset and from IFNβeligibility were examined using survival analyses.Results. LOMS patients (6%) were more likely to be male, with motor onset and a primary-progressive course, and exhibit faster progression and were less likely to take DMDs. Nonetheless, 57% were relapsing-onset, of which 31% were prescribed DMDs, most commonly IFNβ. Among older relapsing-onset MS adults, no significant association between IFNβexposure and disability progression was found when either the contemporary (hazard ratio [HR]: 0.46; 95% CI: 0.18–1.22) or historical controls (HR: 0.54; 95% CI: 0.20–1.42) were considered.Conclusion. LOMS differed clinically from AOMS. One-third of older relapsing-onset MS patients were prescribed a DMD. IFNβexposure was not significantly associated with reduced disability in older MS patients.
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Shirani, A
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Zhao, YS
-
Petkau, J
-
Gustafson, P
-
Karim, ME
-
Evans, C
-
visa fler...
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Kingwell, E
-
van der Kop, ML
-
Oger, J
-
Tremlett, H
-
visa färre...
- Artiklar i publikationen
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BioMed research ...
- Av lärosätet
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Karolinska Institutet