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Autoantibody respon...
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Brozzetti, AUniv Perugia, Dept Internal Med, I-06126 Perugia, Italy.
(författare)
Autoantibody response against NALP5/MATER in primary ovarian insufficiency and in autoimmune Addison's disease
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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The Endocrine Society,2015
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:131628045
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http://kipublications.ki.se/Default.aspx?queryparsed=id:131628045URI
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https://doi.org/10.1210/jc.2014-3571DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-269775URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Context:NACHT leucine-rich-repeat protein 5 (NALP5)/maternal antigen that embryo requires (MATER) is an autoantigen in hypoparathyroidism associated with autoimmune polyendocrine syndrome type 1 (APS1) but is also expressed in the ovary. Mater is an autoantigen in experimental autoimmune oophoritis.Objectives:The objectives of the study were to determine the frequency of NALP5/MATER autoantibodies (NALP5/MATER-Ab) in women with premature ovarian insufficiency (POI) and in patients with autoimmune Addison's disease (AAD) and to evaluate whether inhibin chains are a target for autoantibodies in POI.Methods:Autoantibodies against NALP5/MATER and inhibin chains-α and -βA were determined by radiobinding assays in 172 patients with AAD without clinical signs of gonadal insufficiency, 41 women with both AAD and autoimmune POI [steroidogenic cell autoimmune POI (SCA-POI)], 119 women with idiopathic POI, 19 patients with APS1, and 211 healthy control subjects.Results:NALP5/MATER-Ab were detected in 11 of 19 (58%) sera from APS1 patients, 12 of 172 (7%) AAD sera, 5 of 41 (12%) SCA-POI sera, 0 of 119 idiopathic POI sera and 1 of 211 healthy control sera (P < .001). None of 160 POI sera, including 41 sera from women with SCA-POI and 119 women with idiopathic POI, and none of 211 healthy control sera were positive for inhibin chain-α/βA autoantibodies.Conclusions:NALP5/MATER-Ab are associated with hypoparathyroidism in APS1 but are present also in patients with AAD and in women with SCA-POI without hypoparathyroidism. Inhibin chains do not appear to be likely candidate targets of autoantibodies in human POI.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Alimohammadi, MohammadUppsala universitet,Dermatologi och venereologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)moali133
(författare)
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Morelli, SUniv Perugia, Dept Internal Med, I-06126 Perugia, Italy.
(författare)
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Minarelli, VUniv Perugia, Dept Internal Med, I-06126 Perugia, Italy.
(författare)
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Hallgren, AKarolinska Inst, Dept Med Solna, Ctr Mol Med, S-17176 Stockholm, Sweden.
(författare)
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Giordano, RUniv Turin, Dept Med Sci, Div Endocrinol Diabetol & Metab, I-10126 Turin, Italy.
(författare)
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De Bellis, AUniv Naples 2, Endocrinol Unit, Dept Cardiothorac & Resp Sci, I-80132 Naples, Italy.
(författare)
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Perniola, RV Fazzi Reg Hosp, Dept Pediat Neonatal Intens Care, I-73100 Lecce, Italy.
(författare)
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Kämpe, OlleUppsala universitet,Karolinska Institutet,Autoimmunitet,Science for Life Laboratory, SciLifeLab(Swepub:uu)ollekamp
(författare)
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Falorni, AUniv Perugia, Dept Internal Med, I-06126 Perugia, Italy
(författare)
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Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy.Dermatologi och venereologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The Journal of clinical endocrinology and metabolism: The Endocrine Society100:5, s. 1941-19481945-71970021-972X
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Brozzetti, A
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Alimohammadi, Mo ...
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Morelli, S
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Minarelli, V
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Hallgren, A
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Giordano, R
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visa fler...
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De Bellis, A
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Perniola, R
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Kämpe, Olle
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Falorni, A
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visa färre...
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Karolinska Institutet
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