Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:133463449" > Inverse Relationshi...
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000 | 02891naa a2200385 4500 | |
001 | oai:prod.swepub.kib.ki.se:133463449 | |
003 | SwePub | |
008 | 240913s2016 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1334634492 URI |
024 | 7 | a https://doi.org/10.1155/2016/30853902 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Corona-Meraz, FI4 aut |
245 | 1 0 | a Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance |
264 | 1 | b Hindawi Limited,c 2016 |
520 | a Background. In obesity there is a subclinical chronic low-grade inflammatory response where insulin resistance (IR) may develop. Chemerin is secreted in white adipose tissue and promotes low-grade inflammatory process, where it expressedCMKLR1receptor. The role of chemerin andCMKLR1in inflammatory process secondary to obesity is not defined yet.Methods. Cross-sectional study with 134 individuals classified as with and without obesity by body mass index (BMI) and IR. Body fat storage measurements and metabolic and inflammatory markers were measured by routine methods. Soluble chemerin and basal levels of insulin by ELISA and relative expression ofCMKLR1were evaluated with qPCR and2-ΔΔCTmethod.Results. Differences (P<0.05) were observed between obesity and lean individuals in body fat storage measurements and metabolic-inflammatory markers. BothCMKLR1expression and chemerin levels were increased in obesity without IR. Soluble chemerin levels correlate with adiposity and metabolic markers (r=8.8% to 38.5%),P<0.05.Conclusion. The increment ofCMKLR1expression was associated with insulin production. Increased serum levels of chemerin in obesity were observed, favoring a dysmetabolic response. The results observed in this study suggest that both chemerin andCMKLR1have opposite expression in the context of low-grade inflammatory response manifested in the development of IR. | |
700 | 1 | a Navarro-Hernandez, RE4 aut |
700 | 1 | a Ruiz-Quezada, SL4 aut |
700 | 1 | a Madrigal-Ruiz, PM4 aut |
700 | 1 | a Castro-Albarran, J4 aut |
700 | 1 | a Chavarria-Avila, E4 aut |
700 | 1 | a Guzman-Ornelas, MO4 aut |
700 | 1 | a Gomez-Banuelos, E4 aut |
700 | 1 | a Petri, MH4 aut |
700 | 1 | a Ramirez-Cedano, JI4 aut |
700 | 1 | a Aguilar-Aldrete, ME4 aut |
700 | 1 | a Rios-Ibarra, C4 aut |
700 | 1 | a Vazquez-Del Mercado, M4 aut |
773 | 0 | t Mediators of inflammationd : Hindawi Limitedg 2016, s. 3085390-q 2016<3085390-x 1466-1861x 0962-9351 |
856 | 4 | u http://downloads.hindawi.com/journals/mi/2016/3085390.pdf |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133463449 |
856 | 4 8 | u https://doi.org/10.1155/2016/3085390 |
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