Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:135467654" > Cytosolic 5'-nucleo...
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000 | 03766naa a2200565 4500 | |
001 | oai:prod.swepub.kib.ki.se:135467654 | |
003 | SwePub | |
008 | 240913s2017 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1354676542 URI |
024 | 7 | a https://doi.org/10.1136/annrheumdis-2016-2102822 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lilleker, JB4 aut |
245 | 1 0 | a Cytosolic 5'-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis |
264 | c 2017-01-25 | |
264 | 1 | b BMJ,c 2017 |
520 | a Autoantibodies directed against cytosolic 5′-nucleotidase 1A have been identified in many patients with inclusion body myositis. This retrospective study investigated the association between anticytosolic 5′-nucleotidase 1A antibody status and clinical, serological and histopathological features to explore the utility of this antibody to identify inclusion body myositis subgroups and to predict prognosis.Materials and methodsData from various European inclusion body myositis registries were pooled. Anticytosolic 5′-nucleotidase 1A status was determined by an established ELISA technique. Cases were stratified according to antibody status and comparisons made. Survival and mobility aid requirement analyses were performed using Kaplan-Meier curves and Cox proportional hazards regression.ResultsData from 311 patients were available for analysis; 102 (33%) had anticytosolic 5′-nucleotidase 1A antibodies. Antibody-positive patients had a higher adjusted mortality risk (HR 1.89, 95% CI 1.11 to 3.21, p=0.019), lower frequency of proximal upper limb weakness at disease onset (8% vs 23%, adjusted OR 0.29, 95% CI 0.12 to 0.68, p=0.005) and an increased prevalence of excess of cytochrome oxidase deficient fibres on muscle biopsy analysis (87% vs 72%, adjusted OR 2.80, 95% CI 1.17 to 6.66, p=0.020), compared with antibody-negative patients.InterpretationDifferences were observed in clinical and histopathological features between anticytosolic 5′-nucleotidase 1A antibody positive and negative patients with inclusion body myositis, and antibody-positive patients had a higher adjusted mortality risk. Stratification of inclusion body myositis by anticytosolic 5′-nucleotidase 1A antibody status may be useful, potentially highlighting a distinct inclusion body myositis subtype with a more severe phenotype. | |
700 | 1 | a Rietveld, A4 aut |
700 | 1 | a Pye, SR4 aut |
700 | 1 | a Mariampillai, K4 aut |
700 | 1 | a Benveniste, O4 aut |
700 | 1 | a Peeters, MTJ4 aut |
700 | 1 | a Miller, JAL4 aut |
700 | 1 | a Hanna, MG4 aut |
700 | 1 | a Machado, PM4 aut |
700 | 1 | a Parton, MJ4 aut |
700 | 1 | a Gheorghe, KRu Karolinska Institutet4 aut |
700 | 1 | a Badrising, UA4 aut |
700 | 1 | a Lundberg, IEu Karolinska Institutet4 aut |
700 | 1 | a Sacconi, S4 aut |
700 | 1 | a Herbert, MK4 aut |
700 | 1 | a McHugh, NJ4 aut |
700 | 1 | a Lecky, BRF4 aut |
700 | 1 | a Brierley, C4 aut |
700 | 1 | a Hilton-Jones, D4 aut |
700 | 1 | a Lamb, JA4 aut |
700 | 1 | a Roberts, ME4 aut |
700 | 1 | a Cooper, RG4 aut |
700 | 1 | a Saris, CGJ4 aut |
700 | 1 | a Pruijn, GJM4 aut |
700 | 1 | a Chinoy, H4 aut |
700 | 1 | a van Engelen, BGM4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Annals of the rheumatic diseasesd : BMJg 76:5, s. 862-868q 76:5<862-868x 1468-2060x 0003-4967 |
856 | 4 | u https://ard.bmj.com/content/annrheumdis/76/5/862.full.pdf |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135467654 |
856 | 4 8 | u https://doi.org/10.1136/annrheumdis-2016-210282 |
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