Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:137080481" >
Age Related Multipl...
-
Manouchehrinia, AKarolinska Institutet
(författare)
Age Related Multiple Sclerosis Severity Score: Disability ranked by age
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
-
2017-02-03
-
SAGE Publications,2017
Nummerbeteckningar
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:137080481
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:137080481URI
-
https://doi.org/10.1177/1352458517690618DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
The Multiple Sclerosis Severity Score (MSSS) is obtained by normalising the Expanded Disability Status Scale (EDSS) score for disease duration and has been a valuable tool in cross-sectional studies. Objective: To assess whether use of age rather than the inherently ambiguous disease duration was a feasible approach. Method: We pooled disability data from three population-based cohorts and developed an Age Related Multiple Sclerosis Severity (ARMSS) score by ranking EDSS scores based on the patient’s age at the time of assessment. We established the power to detect a difference between groups afforded by the ARMSS score and assessed its relative consistency over time. Results: The study population included 26058 patients from Sweden ( n = 11846), Canada ( n = 6179) and the United Kingdom ( n = 8033). There was a moderate correlation between EDSS and disease duration ( r = 0.46, 95% confidence interval (CI): 0.45–0.47) and between EDSS and age ( r = 0.44, 95% CI: 0.43–0.45). The ARMSS scores showed comparable power to detect disability differences between groups to the updated and original MSSS. Conclusion: Since age is typically unbiased and readily obtained, and the ARMSS and MSSS were comparable, the ARMSS may provide a more versatile tool and could minimise study biases and loss of statistical power caused by inaccurate or missing onset dates.
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Westerlind, HKarolinska Institutet
(författare)
-
Kingwell, E
(författare)
-
Zhu, F
(författare)
-
Carruthers, R
(författare)
-
Ramanujam, RKarolinska Institutet
(författare)
-
Ban, M
(författare)
-
Glaser, AKarolinska Institutet
(författare)
-
Sawcer, S
(författare)
-
Tremlett, H
(författare)
-
Hillert, JKarolinska Institutet
(författare)
-
Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Multiple sclerosis (Houndmills, Basingstoke, England): SAGE Publications23:14, s. 1938-19461477-09701352-4585
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Manouchehrinia, ...
-
Westerlind, H
-
Kingwell, E
-
Zhu, F
-
Carruthers, R
-
Ramanujam, R
-
visa fler...
-
Ban, M
-
Glaser, A
-
Sawcer, S
-
Tremlett, H
-
Hillert, J
-
visa färre...
- Artiklar i publikationen
-
Multiple scleros ...
- Av lärosätet
-
Karolinska Institutet