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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02016naa a2200301 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:138391840 | |
| 003 | SwePub | |
| 008 | 240701s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1383918402 URI |
| 024 | 7 | a https://doi.org/10.2217/imt-2017-01812 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ahmadi, M4 aut |
| 245 | 1 0 | a Immunization with HER2 extracellular subdomain proteins induces cellular response and tumor growth inhibition in mice |
| 264 | 1 | b Future Medicine Ltd,c 2018 |
| 520 | a Aim: We investigated cellular and protective immune responses in mice vaccinated with recombinant HER2 extracellular subdomains. Materials & methods: Balb/C mice were immunized with recombinant full HER2 extracellular domain and subdomain proteins. Humoral and cellular immune response and antitumor effect was evaluated using a syngeneic mice tumor model. Results: All recombinant proteins induced secretion of IL-4 and particularly IFN-γ and IL-17 cytokines. Challenging of immunized mice with stable 4T1-HER2 transfected cells resulted in partial but significant tumor growth inhibition in all groups of mice particularly those immunized with fHER2-ECD together with CPG. Conclusion: Our results suggest that the recombinant HER2-ECD subdomains induce mainly Th1 and Th17 responses, which seem to contribute to tumor growth inhibition in syngeneic mice. | |
| 700 | 1 | a Sadri-Ardalani, F4 aut |
| 700 | 1 | a Amiri, MM4 aut |
| 700 | 1 | a Jeddi-Tehrani, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Shabani, M4 aut |
| 700 | 1 | a Shokri, F4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Immunotherapyd : Future Medicine Ltdg 10:6, s. 511-524q 10:6<511-524x 1750-7448x 1750-743X |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:138391840 |
| 856 | 4 8 | u https://doi.org/10.2217/imt-2017-0181 |
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