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Different patterns ...
Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years
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- Hofvander, Jakob (författare)
- Lund University,Lunds universitet,Genetiska avvikelser i mjukdelstumörer,Forskargrupper vid Lunds universitet,The genetics of soft tissue tumors,Lund University Research Groups
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- Viklund, Björn (författare)
- Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin
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- Isaksson, Anders (författare)
- Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin
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- Brosjo, O (författare)
- Karolinska Institutet,Karolinska Hosp, Dept Orthoped, SE-17176 Stockholm, Sweden,Karolinska University Hospital
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- Vult von Steyern, Fredrik (författare)
- Lund University,Lunds universitet,Ortopedisk sarkomforskning,Forskargrupper vid Lunds universitet,Orthopaedic Sarcoma Research,Lund University Research Groups,Skåne University Hospital
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- Rissler, Pehr (författare)
- Lund Univ, Dept Clin Genet & Pathol, SE-22185 Lund, Sweden;Reg Labs Reg Skane, SE-22185 Lund, Sweden,Regional Laboratories Region Skåne
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- Mandahl, Nils (författare)
- Lund University,Lunds universitet,Genetiska avvikelser i mjukdelstumörer,Forskargrupper vid Lunds universitet,The genetics of soft tissue tumors,Lund University Research Groups
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- Mertens, Fredrik (författare)
- Lund University,Lunds universitet,Genetiska avvikelser i mjukdelstumörer,Forskargrupper vid Lunds universitet,The genetics of soft tissue tumors,Lund University Research Groups,Regional Laboratories Region Skåne
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(creator_code:org_t)
- 2018-09-10
- 2018
- Engelska.
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 3662-
- Relaterad länk:
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https://www.nature.c...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- To compare clonal evolution in tumors arising through different mechanisms, we selected three types of sarcoma—amplicon-driven well-differentiated liposarcoma (WDLS), gene fusion-driven myxoid liposarcoma (MLS), and sarcomas with complex genomes (CXS)—and assessed the dynamics of chromosome and nucleotide level mutations by cytogenetics, SNP array analysis and whole-exome sequencing. Here we show that the extensive single-cell variation in WDLS has minor impact on clonal key amplicons in chromosome 12. In addition, only a few of the single nucleotide variants in WDLS were present in more than one lesion, suggesting that such mutations are of little significance in tumor development. MLS displays few mutations other than the FUS-DDIT3 fusion, and the primary tumor is genetically sometimes much more complex than its relapses, whereas CXS in general shows a gradual increase of both nucleotide- and chromosome–level mutations, similar to what has been described in carcinomas.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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