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Low plasma haptoglo...
Low plasma haptoglobin is a risk factor for life-threatening childhood severe malarial anemia and not an exclusive consequence of hemolysis
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Abah, SE (författare)
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Burte, F (författare)
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Marquet, S (författare)
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visa fler...
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Brown, BJ (författare)
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Akinkunmi, F (författare)
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Oyinloye, G (författare)
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Afolabi, NK (författare)
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Omokhodion, S (författare)
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Lagunju, I (författare)
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Shokunbi, WA (författare)
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Wahlgren, M (författare)
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Dessein, H (författare)
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Argiro, L (författare)
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Dessein, AJ (författare)
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Noyvert, B (författare)
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Hunt, L (författare)
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Elgar, G (författare)
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Sodeinde, O (författare)
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Holder, AA (författare)
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Fernandez-Reyes, D (författare)
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- 2018-12-03
- 2018
- Engelska.
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1, s. 17527-
- Relaterad länk:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Severe Malarial Anemia (SMA), a life-threatening childhood Plasmodium falciparum malaria syndrome requiring urgent blood transfusion, exhibits inflammatory and hemolytic pathology. Differentiating between hypo-haptoglobinemia due to hemolysis or that of genetic origin is key to understand SMA pathogenesis. We hypothesized that while malaria-induced hypo-haptoglobinemia should reverse at recovery, that of genetic etiology should not. We carried-out a case-control study of children living under hyper-endemic holoendemic malaria burden in the sub-Saharan metropolis of Ibadan, Nigeria. We show that hypo-haptoglobinemia is a risk factor for childhood SMA and not solely due to intravascular hemolysis from underlying schizogony. In children presenting with SMA, hypo-haptoglobinemia remains through convalescence to recovery suggesting a genetic cause. We identified a haptoglobin gene variant, rs12162087 (g.-1203G > A, frequency = 0.67), to be associated with plasma haptoglobin levels (p = 8.5 × 10−6). The Homo-Var:(AA) is associated with high plasma haptoglobin while the reference Homo-Ref:(GG) is associated with hypo-haptoglobinemia (p = 2.3 × 10−6). The variant is associated with SMA, with the most support for a risk effect for Homo-Ref genotype. Our insights on regulatory haptoglobin genotypes and hypo-haptoglobinemia suggest that haptoglobin screening could be part of risk-assessment algorithms to prevent rapid disease progression towards SMA in regions with no-access to urgent blood transfusion where SMA accounts for high childhood mortality rates.
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Till lärosätets databas
- Av författaren/redakt...
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Abah, SE
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Burte, F
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Marquet, S
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Brown, BJ
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Akinkunmi, F
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Oyinloye, G
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visa fler...
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Afolabi, NK
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Omokhodion, S
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Lagunju, I
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Shokunbi, WA
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Wahlgren, M
-
Dessein, H
-
Argiro, L
-
Dessein, AJ
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Noyvert, B
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Hunt, L
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Elgar, G
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Sodeinde, O
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Holder, AA
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Fernandez-Reyes, ...
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visa färre...
- Artiklar i publikationen
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Scientific repor ...
- Av lärosätet
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Karolinska Institutet