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Salivary IgA to MAA...
Salivary IgA to MAA-LDL and Oral Pathogens Are Linked to Coronary Disease
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-01-22
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SAGE Publications,2019
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:140333818
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140333818URI
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https://doi.org/10.1177/0022034518818445DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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A large body of literature has established the link between periodontal disease and cardiovascular disease. Oxidized low-density lipoproteins (OxLDLs) have a crucial role in atherosclerosis progression through initiation of immunological response. Monoclonal IgM antibodies to malondialdehyde-modified low-density lipoprotein (MDA-LDL) and to malondialdehyde acetaldehyde–modified low-density lipoprotein (MAA-LDL) have been shown to cross-react with the key virulence factors of periodontal pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. We have previously shown that salivary IgA antibodies to MAA-LDL cross-react with P. gingivalis in healthy humans. In this study, we aim to assess whether oral mucosal immune response represented by salivary IgA to MAA-LDL and oral pathogens is associated with coronary artery disease (CAD). Also, the molecular mimicry through antibody cross-reaction between salivary IgA to MAA-LDL and oral pathogens was evaluated. The study subjects consisted of 451 patients who underwent a coronary angiography with no CAD ( n = 133), stable CAD ( n = 169), and acute coronary syndrome (ACS, n = 149). Elevated salivary IgA antibody levels to MAA-LDL, Rgp44 (gingipain A hemagglutinin domain of P. gingivalis), and Aa-HSP60 (heat shock protein 60 of A. actinomycetemcomitans) were discovered in stable-CAD and ACS patients when compared to no-CAD patients. In a multinomial regression model adjusted for known cardiovascular risk factors, stable CAD and ACS were associated with IgA to MAA-LDL ( P = 0.016, P = 0.043), Rgp44 ( P = 0.012, P = 0.004), Aa-HSP60 ( P = 0.032, P = 0.030), Tannerella forsythia ( P = 0.002, P = 0.004), Porphyromonas endodontalis ( P = 0.016, P = 0.020), Prevotella intermedia ( P = 0.038, P = 0.005), and with total IgA antibody concentration ( P = 0.002, P = 0.016). Salivary IgA to MAA-LDL showed cross-reactivity with the oral pathogens tested in the study patients. The study highlights an association between salivary IgA to MAA-LDL and atherosclerosis. However, whether salivary IgA to MAA-LDL and the related oral humoral responses play a causal role in the development in the CAD should be elucidated in the future.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wang, C
(författare)
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Nissinen, AE
(författare)
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Kankaanpaa, J
(författare)
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Bloigu, R
(författare)
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Paju, S
(författare)
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Mantyla, P
(författare)
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Buhlin, KKarolinska Institutet
(författare)
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Sinisalo, J
(författare)
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Pussinen, PJ
(författare)
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Horkko, S
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of dental research: SAGE Publications98:3, s. 296-3031544-05910022-0345
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Till lärosätets databas
- Av författaren/redakt...
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Akhi, R
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Wang, C
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Nissinen, AE
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Kankaanpaa, J
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Bloigu, R
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Paju, S
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visa fler...
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Mantyla, P
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Buhlin, K
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Sinisalo, J
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Pussinen, PJ
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Horkko, S
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visa färre...
- Artiklar i publikationen
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Journal of denta ...
- Av lärosätet
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Karolinska Institutet