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The Prognostic Role...
The Prognostic Roles of Pretreatment Circulating Tumor Cells, Circulating Cancer Stem-Like Cells, and Programmed Cell Death-1 Expression on Peripheral Lymphocytes in Patients with Initially Unresectable, Recurrent or Metastatic Head and Neck Cancer: An Exploratory Study of Three Biomarkers in One-time Blood Drawing
- Artikel/kapitelEngelska2019
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Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:140947883
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140947883URI
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https://doi.org/10.3390/cancers11040540DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Circulating tumor cells (CTCs) and immune status are strongly related to cancer prognosis, although few studies have examined both factors. This prospective observational study (ClinicalTrials.gov: NCT02420600) evaluated whether CTCs, circulating cancer stem-like cells (cCSCs), and peripheral lymphocytes with/without Programmed cell death protein 1 (PD-1) expression were associated with prognosis among patients receiving palliative chemotherapy for initially unresectable, recurrent/metastatic head and neck squamous cell carcinoma (rmHNSCC). Thirty-four patients were enrolled between January 2015 and June 2016. Overall survival (OS) was associated with a higher CTC number (hazard ratio [HR]: 1.01, p = 0.0004) and cCSC ratio (HR: 29.903, p < 0.0001). Progression-free survival (PFS) was also associated with CTC number (HR: 1.013, p = 0.002) and cCSC ratio (HR: 10.92, p = 0.003). A CD8+ proportion of ≥ 17% was associated with improved OS (HR: 0.242, p = 0.004). A CD4: CD8 ratio of >1.2 was associated with poorer trend of PFS (HR: 2.12, p = 0.064). PD-1 expression was not associated with survival outcomes. Baseline CTCs, cCSC ratio, and CD8+ ratio may predict prognosis in rmHNSCC.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wu, MH
(författare)
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Liu, SY
(författare)
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Wang, HM
(författare)
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Huang, WKKarolinska Institutet
(författare)
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Liao, CT
(författare)
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Yen, TC
(författare)
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Ng, SH
(författare)
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Chen, JS
(författare)
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Lin, YC
(författare)
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Lin, HC
(författare)
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Hsieh, JCH
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cancers: MDPI AG11:42072-6694
Internetlänk
Hitta via bibliotek
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Cancers
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
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Chang, PH
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Wu, MH
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Liu, SY
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Wang, HM
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Huang, WK
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Liao, CT
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visa fler...
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Yen, TC
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Ng, SH
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Chen, JS
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Lin, YC
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Lin, HC
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Hsieh, JCH
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visa färre...
- Artiklar i publikationen
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Cancers
- Av lärosätet
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Karolinska Institutet