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Role of the galanin...
Role of the galanin N-terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system
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Millon, C (författare)
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Flores-Burgess, A (författare)
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Gago, B (författare)
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Alen, F (författare)
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Orio, L (författare)
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Garcia-Duran, L (författare)
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Narvaez, JA (författare)
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- Fuxe, K (författare)
- Karolinska Institutet
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Santin, L (författare)
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Diaz-Cabiale, Z (författare)
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(creator_code:org_t)
- 2019-05-13
- 2019
- Engelska.
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Ingår i: Journal of psychopharmacology (Oxford, England). - : SAGE Publications. - 1461-7285 .- 0269-8811. ; 33:6, s. 737-747
- Relaterad länk:
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https://riuma.uma.es...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Anhedonia is a core feature of depressive disorders. The galanin N-terminal fragment (1-15) plays a role in mood regulation since it induces depression and anxiogenic-like effects in rats. In this study, we analysed galanin N-terminal fragment (1-15) actions in anhedonic-like behaviours in rats using operant and non-operant tests and the areas involved with these effects. Methods: Galanin N-terminal fragment (1-15) effects were analysed in saccharin self-administration, sucrose preference, novelty-suppressed feeding and female urine sniffing tests. The areas involved in galanin N-terminal fragment (1-15)-mediated effects were studied with positron emission tomography for in vivo imaging, and we analysed the ventral tegmental area and nucleus accumbens. Galanin N-terminal fragment (1-15) had effects on the mRNA expression of the dopamine transporters Dat and Vmat2; the C-Fos gene; the dopamine receptors D1, D2, D3, D5; and the galanin receptors 1 and 2. Results: Galanin N-terminal fragment (1-15) at a concentration of 3 nmol induced a strong anhedonia-like phenotype in all tests. The involvement of galanin receptor 2 was demonstrated with the galanin receptor 2 antagonist M871 (3 nmol). The 18F-fluorodeoxyglucose positron emission tomography images indicated the action of galanin N-terminal fragment (1-15) over several nuclei of the limbic system. Galanin N-terminal fragment (1-15)-mediated effects also involved changes in the expression of Dat, Vmat2, D3 and galanin receptors in the ventral tegmental area as well as the expression of C-Fos, D1, D2 and D3 and TH immunoreactivity in the nucleus accumbens. Conclusions: Our results indicated that galanin N-terminal fragment (1-15) exerts strong anhedonic-like effects and that this effect was accompanied by changes in the dopaminergic mesolimbic system. These results may provide a basis for the development of novel therapeutic strategies using galanin N-terminal fragment (1-15) analogues for the treatment of depression and reward-related diseases.
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Millon, C
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Flores-Burgess, ...
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Gago, B
-
Alen, F
-
Orio, L
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Garcia-Duran, L
-
visa fler...
-
Narvaez, JA
-
Fuxe, K
-
Santin, L
-
Diaz-Cabiale, Z
-
visa färre...
- Artiklar i publikationen
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Journal of psych ...
- Av lärosätet
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Karolinska Institutet